2024
The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias
Gatto N, Renz A, Tom S, Lyons M, Macuiba J, Dodd T, Lind B, Gray S, Meyers K, Larson E, Nelson J, McEvoy L, Sankaran S, Key D, Litondo J, Crane P. The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias. Brain Sciences 2024, 14: 1075. DOI: 10.3390/brainsci14111075.Peer-Reviewed Original ResearchAdult ChangesMembers of Kaiser Permanente WashingtonKaiser Permanente WashingtonAbstracted medical recordsMedical recordsOlder adult membersProspective cohort studyWomen's healthRelated dementiaEpidemiological researchPharmacy dataLongitudinal clinical dataCohort studyAbstracted dataMedical conditionsBehavioral factorsAlzheimer's diseasePhysical injuryDementiaParticipantsBrain autopsyBlood pressureEpidemiological investigationsPsychosocialAct dataSafety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies
Getahun D, Liu I, Sy L, Glanz J, Zerbo O, Vazquez-Benitez G, Nelson J, Williams J, Hambidge S, McLean H, Irving S, Weintraub E, Qian L. Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies. JAMA Network Open 2024, 7: e2434857. PMID: 39298167, PMCID: PMC11413712, DOI: 10.1001/jamanetworkopen.2024.34857.Peer-Reviewed Original ResearchConceptsAdverse perinatal outcomesPreterm premature rupture of membranesPremature rupture of membranesPreterm premature ruptureRupture of membranesRisk of preeclampsiaSeasonal influenza vaccineInfluenza vaccineAssociated with increased riskInterpregnancy intervalPerinatal outcomesVaccine typesPlacental abruptionPreterm birthInfluenza seasonAssociated with increased risk of preeclampsiaCohort studyRisk of adverse perinatal outcomesAssociated with increased risk of adverse perinatal outcomesSingleton live birth pregnanciesRelative riskLive-birth pregnanciesGestational age birthsRetrospective cohort studyAdjusted relative risksTinnitus after COVID-19 vaccination: Findings from the vaccine adverse event reporting system and the vaccine safety datalink
Yih W, Duffy J, Su J, Bazel S, Fireman B, Hurley L, Maro J, Marquez P, Moro P, Nair N, Nelson J, Smith N, Sundaram M, Vasquez-Benitez G, Weintraub E, Xu S, Shimabukuro T. Tinnitus after COVID-19 vaccination: Findings from the vaccine adverse event reporting system and the vaccine safety datalink. American Journal Of Otolaryngology 2024, 45: 104448. PMID: 39096568, DOI: 10.1016/j.amjoto.2024.104448.Peer-Reviewed Original ResearchVaccine Adverse Event Reporting SystemVaccine Safety DatalinkReports of tinnitusInfluenza vaccineAdverse Event Reporting SystemEvent Reporting SystemCOVID-19 vaccineIncreased risk of tinnitusIncidence rateRisk of tinnitusVaccine safety surveillance systemOccurrence of tinnitusEmpirical Bayesian data miningCOVID-19 vaccine dosesDay 1Increased riskTinnitusVaccine doseInfluenzaConfounding factorsDisproportionate reportingSafety surveillance systemMedical visitsVaccineAge groupsChildhood executive control and adolescent substance use: Mediation via parent–child relationship quality
Patwardhan I, Guo Y, Fleming C, James T, Nelson J, Espy K, Nelson T, Mason W. Childhood executive control and adolescent substance use: Mediation via parent–child relationship quality. Family Relations 2024, 73: 3513-3529. DOI: 10.1111/fare.13061.Peer-Reviewed Original ResearchAdolescent substance usePreschool ECExecutive controlHarsh disciplineSubstance useContribution of child characteristicsLongitudinal cohort-sequential studyParent-child relationship qualityFamily history of substance usePreschool executive controlStatistically significant indirect effectCohort-sequential studyAffecting qualityHistory of substance useSignificant indirect effectSubstance use initiationE-cigarettesFamily socioeconomic statusMethod ParticipantsParenting behaviorsMediation analysisRelationship qualityAdolescent assessmentIndirect associationsChild characteristicsAdolescent Sleep as a Transdiagnostic Factor: Associations Between Actigraphy-Derived Night-to-Night Sleep Metrics and Adolescent Psychopathology
Phillips E, Goldberg E, Brock R, Hamburger E, Nelson J, Mason W, Espy K, Nelson T. Adolescent Sleep as a Transdiagnostic Factor: Associations Between Actigraphy-Derived Night-to-Night Sleep Metrics and Adolescent Psychopathology. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.06.001.Peer-Reviewed Original ResearchMultilevel structural equation modelingBifactor S-1 modelIntraindividual variabilityModels of psychopathologySleep metricsSleep durationTransdiagnostic factorAdolescent psychopathologyEmotion dysregulationPsychopathologyStructural equation modelingGeneral factorPsychiatric problemsLatent meansAdolescent sleepNight sleep durationSocioeconomic riskResults ResultsEquation modelingAdolescentsSociodemographic variablesSleepPositive associationDysregulationBifactorEarly childhood executive control modulates negative affectivity's role in increasing adolescent body mass index trajectories
Tomaso C, James T, Brock R, Yaroch A, Hill J, Huang T, Nelson J, Mason W, Espy K, Nelson T. Early childhood executive control modulates negative affectivity's role in increasing adolescent body mass index trajectories. Pediatric Obesity 2024, 19: e13144. PMID: 38926799, DOI: 10.1111/ijpo.13144.Peer-Reviewed Original ResearchExecutive control abilitiesExecutive controlNegative affectExecutive control tasksChild Behavior QuestionnaireControl abilityEarly risk factorsEarly temperamentAssess temperamentBehavior QuestionnaireTemperamentControl taskLongitudinal studyAffectAssociated with pediatric obesityBMI growthRisk factorsTargeted assessmentWeight outcomesAffective rolesPrevention effortsChildrenChildhood obesity prevention effortsObesity prevention effortsBody mass index trajectoriesMaternal and child health intervention to promote behaviour change: a population-level cluster-randomised controlled trial in Honduras
Oles W, Alexander M, Negron R, Nelson J, Iriarte E, Airoldi E, Christakis N, Forastiere L. Maternal and child health intervention to promote behaviour change: a population-level cluster-randomised controlled trial in Honduras. BMJ Open 2024, 14: e060784. PMID: 38858139, PMCID: PMC11168147, DOI: 10.1136/bmjopen-2022-060784.Peer-Reviewed Original ResearchConceptsCluster randomised controlled trialPrimary outcomeCounseling interventionChild health interventionsCommunity health workersProfessional care seekingBreast-feedingPromote behavior changeSecondary outcome measuresFacility birthsUmbilical cord careCare-seekingNewborn healthNewborn careHealth workersHealth facilitiesEndline surveyHealth interventionsEducational interventionChild healthCord careHome settingCaring behaviorsSecondary outcomesSustained educational interventionsCoronavirus Disease 2019 (COVID-19) Vaccination and Stillbirth in the Vaccine Safety Datalink
Denoble A, Vazquez-Benitez G, Sheth S, Ackerman-Banks C, DeSilva M, Zhu J, Daley M, Getahun D, Klein N, Vesco K, Irving S, Nelson J, Williams J, Hambidge S, Donahue J, Weintraub E, Kharbanda E, Lipkind H. Coronavirus Disease 2019 (COVID-19) Vaccination and Stillbirth in the Vaccine Safety Datalink. Obstetrics And Gynecology 2024, 144: 215-222. PMID: 38843526, PMCID: PMC11250101, DOI: 10.1097/aog.0000000000005632.Peer-Reviewed Original ResearchVaccine Safety DatalinkAntepartum stillbirthVaccine Safety Datalink sitesLive birthsCOVID-19 vaccineVaccine dosePregnancy start dateRisk of severe morbidityRisk of stillbirthConditional logistic regressionCase-control studyVaccine manufacturersSingleton pregnanciesGestational ageFetal deathPostpartum visitMaternal ageIndex dateSevere morbidityDiagnostic codesPregnancyStillbirthPregnant peopleCOVID-19Logistic regressionPost-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection
Malden D, Liu I, Qian L, Sy L, Lewin B, Asamura D, Ryan D, Bezi C, Williams J, Kaiser R, Daley M, Nelson J, McClure D, Zerbo O, Henninger M, Fuller C, Weintraub E, Saydah S, Tartof S. Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection. Nature Communications 2024, 15: 4101. PMID: 38778026, PMCID: PMC11111703, DOI: 10.1038/s41467-024-48022-9.Peer-Reviewed Original ResearchConceptsElectronic health recordsPost-COVID conditionsMatched cohort studyRetrospective matched cohort studyRelative riskCohort studyAdjusted relative risksSARS-CoV-2 positive testAssociated with reduced riskMental health disordersPositive SARS-CoV-2 testLow riskLong-term consequences of COVID-19Health recordsSARS-CoV-2 testingPoisson regressionHealth disordersHealthcare systemCOVID-19SARS-CoV-2 infectionConsequences of COVID-19Younger ageCOVID-19 casesSARS-CoV-2Long-term consequencesAssociations between middle childhood executive control aspects and adolescent substance use and externalizing and internalizing problems
Mason W, Fleming C, Patwardhan I, Guo Y, James T, Nelson J, Espy K, Nelson T. Associations between middle childhood executive control aspects and adolescent substance use and externalizing and internalizing problems. Journal Of Research On Adolescence 2024, 34: 791-804. PMID: 38757393, PMCID: PMC11349481, DOI: 10.1111/jora.12943.Peer-Reviewed Original ResearchAdolescent substance useInternalizing problemsWorking memorySubstance useAssociated with externalizing problemsConfirmatory factor analysisChildhood externalizingExternalizing problemsStructural equation modelingAdolescent outcomesFactor analysisStronger predictionEquation modelingSociodemographic covariatesMidwestern cityMemoryFinding uncoded anaphylaxis in electronic health records to estimate the sensitivity of International Classification of Diseases, Tenth Revision, Clinical Modification codes
Hazlehurst B, Carrell D, Bann M, Nelson J, Gruber S, Slaughter M, Cronkite D, Ball R, Floyd J. Finding uncoded anaphylaxis in electronic health records to estimate the sensitivity of International Classification of Diseases, Tenth Revision, Clinical Modification codes. American Journal Of Epidemiology 2024, 193: 1494-1496. PMID: 38751242, DOI: 10.1093/aje/kwae063.Peer-Reviewed Original ResearchA general framework for developing computable clinical phenotype algorithms
Carrell D, Floyd J, Gruber S, Hazlehurst B, Heagerty P, Nelson J, Williamson B, Ball R. A general framework for developing computable clinical phenotype algorithms. Journal Of The American Medical Informatics Association 2024, 31: 1785-1796. PMID: 38748991, PMCID: PMC11258420, DOI: 10.1093/jamia/ocae121.Peer-Reviewed Original ResearchNatural language processing methodsStage of algorithm developmentElectronic health record dataLanguage processing methodsHealth record dataGold standard dataMachine learningDevelopment of computational algorithmsPhenotyping algorithmsAlgorithm developmentAlgorithmPractice guidelinesRecord dataAlgorithm development processComputational algorithmDevelopment processProcessing methodsDevelopment projectsStandard dataModel evaluationClinical medicineGuidelinesPractical guidanceInformaticsHealthcareAttitudes Toward COVID-19 Vaccines Among Pregnant and Recently Pregnant Individuals
Williams J, Kurlandsky K, Breslin K, Durfee M, Stein A, Hurley L, Shoup J, Reifler L, Daley M, Lewin B, Goddard K, Henninger M, Nelson J, Vazquez-Benitez G, Hanson K, Fuller C, Weintraub E, McNeil M, Hambidge S. Attitudes Toward COVID-19 Vaccines Among Pregnant and Recently Pregnant Individuals. JAMA Network Open 2024, 7: e245479. PMID: 38587844, PMCID: PMC11002697, DOI: 10.1001/jamanetworkopen.2024.5479.Peer-Reviewed Original ResearchConceptsVaccine Safety DatalinkHispanic respondentsHigher risk of severe COVID-19 outcomesPregnant peopleNon-Hispanic white respondentsCross-sectional survey studyWave 2Centers for Disease Control and PreventionNon-Hispanic blacksUS Centers for Disease Control and PreventionSpanish-speaking membersHealth care systemVaccination statusDisease Control and PreventionPublic health messagesRisk of severe COVID-19 outcomesControl and PreventionSelf-reported vaccination statusProportion of respondentsPublic health concernSevere COVID-19 outcomesNon-HispanicCare systemHealth messagesMain OutcomesInfluenza vaccination accuracy among adults: Self-report compared with electronic health record data
Daley M, Reifler L, Shoup J, Glanz J, Lewin B, Klein N, Kharbanda E, McLean H, Hambidge S, Nelson J, Naleway A, Weintraub E, McNeil M, Razzaghi H, Singleton J. Influenza vaccination accuracy among adults: Self-report compared with electronic health record data. Vaccine 2024, 42: 2740-2746. PMID: 38531726, PMCID: PMC11238074, DOI: 10.1016/j.vaccine.2024.03.052.Peer-Reviewed Original ResearchInfluenza seasonNegative predictive valueVaccination dataSelf-reportInfluenza vaccineElectronic health record dataRandom sample of adultsHealth record dataCriterion standardInfluenzaModerate concordancePredictive valueResponse rateSurvey response rateSample of adultsVaccination statusSurvey yearRecord dataResearch NetworkRandom sampleAdultsTargeted learning with an undersmoothed LASSO propensity score model for large-scale covariate adjustment in health-care database studies
Wyss R, van der Laan M, Gruber S, Shi X, Lee H, Dutcher S, Nelson J, Toh S, Russo M, Wang S, Desai R, Lin K. Targeted learning with an undersmoothed LASSO propensity score model for large-scale covariate adjustment in health-care database studies. American Journal Of Epidemiology 2024, kwae023. PMID: 38517025, DOI: 10.1093/aje/kwae023.Peer-Reviewed Original ResearchConfounding controlLarge-scale propensity scoreDatabase studyPropensity scoreHealthcare database studiesCovariate distributionsPS modelCovariate adjustmentReduce biasData-adaptivePropensity score modelNon-overlappingEstimate treatment effectsCovariate overlapCross-fittingHealthcareTarget learningConfoundingRobust frameworkUndersmoothingCollaborative learningTreatment effectsLearningLASSOLASSO regressionProcess guide for inferential studies using healthcare data from routine clinical practice to evaluate causal effects of drugs (PRINCIPLED): considerations from the FDA Sentinel Innovation Center
Desai R, Wang S, Sreedhara S, Zabotka L, Khosrow-Khavar F, Nelson J, Shi X, Toh S, Wyss R, Patorno E, Dutcher S, Li J, Lee H, Ball R, Dal Pan G, Segal J, Suissa S, Rothman K, Greenland S, Hernán M, Heagerty P, Schneeweiss S. Process guide for inferential studies using healthcare data from routine clinical practice to evaluate causal effects of drugs (PRINCIPLED): considerations from the FDA Sentinel Innovation Center. The BMJ 2024, 384: e076460. PMID: 38346815, DOI: 10.1136/bmj-2023-076460.Peer-Reviewed Original ResearchComparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing
Mossa-Basha M, Andre J, Yuh E, Hunt D, LaPiana N, Howlett B, Krakauer C, Crane P, Nelson J, DeZelar M, Meyers K, Larson E, Ralston J, Mac Donald C. Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing. British Journal Of Radiology 2024, 97: 614-621. PMID: 38303547, PMCID: PMC11027291, DOI: 10.1093/bjr/tqae004.Peer-Reviewed Original ResearchConceptsCommon Data ElementsMRI groupThought (ACTClinical health measuresResearch MRIAging populationWhite matter hyperintensityPrevalence of hypertensionBrain MRI measuresMRI scansNeuroimaging cohortMRI participantsAdult ChangesPhysical healthHealth measuresOverall healthOutcome measuresResearch cohortBrain imagingWMH burdenCongestive heart failureData elementsBrainMRI measurementsMRI metricsImpact of the COVID-19 Pandemic on Health Care Utilization in the Vaccine Safety Datalink: Retrospective Cohort Study
Qian L, Sy L, Hong V, Glenn S, Ryan D, Nelson J, Hambidge S, Crane B, Zerbo O, DeSilva M, Glanz J, Donahue J, Liles E, Duffy J, Xu S. Impact of the COVID-19 Pandemic on Health Care Utilization in the Vaccine Safety Datalink: Retrospective Cohort Study. JMIR Public Health And Surveillance 2024, 10: e48159. PMID: 38091476, PMCID: PMC10807656, DOI: 10.2196/48159.Peer-Reviewed Original ResearchKaiser Permanente Southern CaliforniaHealth care utilizationLater pandemic periodsRetrospective cohort studyElectronic health record dataPre-pandemic levelsEarly pandemic periodHealth record dataCare utilizationCare settingsVisit ratesPre-pandemic periodED visitsCohort studyEmergency departmentCOVID-19Vaccine Safety Datalink ProjectHealth care organizationsCOVID-19 pandemicVaccine Safety DatalinkRecord dataEntire study populationPandemic periodCare organizationsHealth care settings
2023
The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias
Crane P, Lind B, Dodd T, Lyons M, Macuiba J, Gray S, Meyers K, Kelley A, Nemerever L, Covey J, Campbell C, Lederman B, Sheridan L, Tom S, Larson E, Nelson J, LaCroix A, Renz A. The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A resource for research on the aging brain and Alzheimer’s disease and related dementias. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079041.Peer-Reviewed Original ResearchMedical recordsClinical dataMedical conditionsAlzheimer's diseaseAdult ChangesElectronic medical record dataProspective cohort studyClinical-pathological correlationChart review dataLaboratory dataMedical record dataLongitudinal clinical dataAutopsy cohortCerebrovascular accidentCohort studyBlood pressureMedication dataPharmacy dataDementia statusCardiovascular conditionsNeurological conditionsDementia diagnosisAbstract medical recordsPsychiatric conditionsAnalysis of associationExploring the Interaction Between Preschool Executive Control and Caregiver Emotion Socialization in Predicting Adolescent Weight Trajectories
Laifer L, Brock R, Tomaso C, James T, Yaroch A, Hill J, Huang T, Nelson J, Mason W, Espy K, Nelson T. Exploring the Interaction Between Preschool Executive Control and Caregiver Emotion Socialization in Predicting Adolescent Weight Trajectories. Journal Of Youth And Adolescence 2023, 53: 656-668. PMID: 38117361, PMCID: PMC10872396, DOI: 10.1007/s10964-023-01928-x.Peer-Reviewed Original ResearchPreschool executive controlEmotion-related socialization behaviorsCaregiver emotion socializationExecutive controlSupportive responsesEmotion socializationSocialization behaviorsExecutive control tasksLower executive controlEmotion socialization practicesSelf-regulatory abilitiesSelf-regulatory resourcesFamily factorsImportance of effortsLongitudinal designNeural vulnerabilitySocialization practicesControl taskExternal regulationLaboratory visitsAge 14Longitudinal studyAdolescenceParticipantsNegative association