2009
The dynamic effects of nicotine on the developing brain
Dwyer JB, McQuown SC, Leslie FM. The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics 2009, 122: 125-139. PMID: 19268688, PMCID: PMC2746456, DOI: 10.1016/j.pharmthera.2009.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsBrainFetal DevelopmentHumansInfantInfant, NewbornNicotineRatsReceptors, NicotinicConceptsNicotine exposureDevelopmental influencesAdolescent periodBrain maturationExogenous nicotineHuman brainUnique effectsMaturational periodNeural structuresLimbic systemClinical literatureNicotine replacement therapyEnvironmental stimuliEarly postnatal periodPreclinical animal modelsDevelopmental windowNicotinic acetylcholine receptorsPrenatal periodReplacement therapyEarly postnatalPostnatal periodTobacco smokeAnimal modelsAcetylcholine receptorsNicotine
2008
Nicotine and brain development
Dwyer JB, Broide RS, Leslie FM. Nicotine and brain development. Birth Defects Research Part C Embryo Today Reviews 2008, 84: 30-44. PMID: 18383130, DOI: 10.1002/bdrc.20118.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyMaternal smokingPharmacologic propertiesBrain developmentSudden infant death syndromeFetal central nervous systemAuditory cognitive dysfunctionActivation of nAChRsInfant death syndromeCentral nervous systemNumerous brain regionsNicotinic acetylcholine receptorsCell survivalLigand-gated ion channelsLong-term alterationsSpecific neural circuitryCritical developmental periodPregnant womenReplacement therapyTobacco cessationCholinergic modulationFunctional statusNeonatal brainPreclinical studiesTransmitter release