2024
Co-existing chronic hypertension and hypertensive disorders of pregnancy and associated adverse pregnancy outcomes
Sweeney L, Lundsberg L, Culhane J, Partridge C, Son M. Co-existing chronic hypertension and hypertensive disorders of pregnancy and associated adverse pregnancy outcomes. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2305675. PMID: 38290827, DOI: 10.1080/14767058.2024.2305675.Peer-Reviewed Original ResearchConceptsHypertensive disorders of pregnancyDisorders of pregnancyNeonatal outcomesChronic hypertensionHypertensive disordersIntensive care unitCesarean deliveryOdds of cesarean deliveryPregnant personsBlood pressureBivariate tests of associationHypertensive conditionsMaternal ICU admissionPreterm birth <Intensive care unit admissionAntihypertensive medication useBaseline clinical dataElectronic medical recordsTests of associationRetrospective cohort studySGA birthweightEligible peopleGestational ageMaternal comorbiditiesSingleton deliveriesRate of clinically significant red blood cell antibody seroconversion in pregnancy
Ding J, Abels E, Jacobs J, Culhane J, Lundsberg L, Partridge C, Denoble A, Kohari K. Rate of clinically significant red blood cell antibody seroconversion in pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2419370. PMID: 39462637, DOI: 10.1080/14767058.2024.2419370.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitAdvanced maternal ageAssociated with seroconversionClinically significant antibodiesAntibody screeningNeonatal outcomesIncreasing gravidityAntibody seroconversionInitial hemoglobinMaternal ageSignificant antibodiesAntibody statusNeonatal intensive care unit admissionCohort studyClinically significant RBC antibodiesAnti-CUnexplained fetal lossPositive antibody screenNegative antibody screenCases of stillbirthRetrospective cohort studyIntensive care unitWilcoxon rank-sumMaternal antibody statusPostnatal transfusion
2023
The association between a low 50-gram, 1-hour glucose challenge test value and neonatal morbidity
Ding J, Lundsberg L, Culhane J, Patridge C, Milley L, Son M. The association between a low 50-gram, 1-hour glucose challenge test value and neonatal morbidity. The Journal Of Maternal-Fetal & Neonatal Medicine 2023, 36: 2245527. PMID: 37558273, DOI: 10.1080/14767058.2023.2245527.Peer-Reviewed Original ResearchConceptsGlucose challenge test valuesTertiary care academic hospitalDiagnosis of GDMGlycemic screeningGCT valuesNICU admissionNeonatal outcomesMorbidity outcomesAcademic hospitalNeonatal intensive care unit admissionSingle tertiary care academic hospitalIntensive care unit admissionMultivariable logistic regression modelingComposite morbidity outcomeNeonatal morbidity outcomesCare unit admissionRetrospective cohort studyNewborns of mothersRisk of morbidityLogistic regression modelingEligible patientsUnit admissionAntenatal surveillanceGestational diabetesHypertensive disordersFetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use?
Leon-Martinez D, Lundsberg L, Culhane J, Zhang J, Son M, Reddy U. Fetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use? American Journal Of Obstetrics And Gynecology 2023, 229: 678.e1-678.e16. PMID: 37348779, DOI: 10.1016/j.ajog.2023.06.035.Peer-Reviewed Original ResearchConceptsNeonatal composite outcomeComposite outcomeFetal growth restrictionGestational ageFetal weightWeeks of gestationPositive likelihood ratioGrowth restrictionNonanomalous singleton pregnanciesPoor neonatal outcomeRetrospective cohort studySingle academic centerWeeks of deliveryDays of deliveryFetal growth referencesElectronic medical recordsProportion of fetusesLikelihood ratioNeonatal morbidityNeonatal outcomesPerinatal outcomesCohort studySingleton pregnanciesNeonatal dataMedical recordsIntravenous iron for treatment of iron deficiency anemia during pregnancy and associated maternal outcomes
Burn M, Lundsberg L, Culhane J, Partridge C, Son M. Intravenous iron for treatment of iron deficiency anemia during pregnancy and associated maternal outcomes. The Journal Of Maternal-Fetal & Neonatal Medicine 2023, 36: 2192855. PMID: 36958808, DOI: 10.1080/14767058.2023.2192855.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAnemiaAnemia, Iron-DeficiencyFemaleHumansInfant, NewbornIronPregnancyRetrospective StudiesConceptsIron deficiency anemiaMaternal morbidity compositeIntravenous ironMorbidity compositePotential confoundersElectronic medical recordsPregnant patientsTreatment courseDeficiency anemiaHigh-risk baseline characteristicsMultivariable logistic regression modellingRetrospective cohort studyFull treatment courseHospital electronic medical recordsIntensive care unitLogistic regression modellingGreater increaseMaternal morbidityMaternal outcomesNeonatal outcomesBaseline characteristicsCohort studyBlood transfusionPrimary outcomeTerm delivery
2005
Maternal Infection and Adverse Fetal and Neonatal Outcomes
Goldenberg R, Culhane J, Johnson D. Maternal Infection and Adverse Fetal and Neonatal Outcomes. Clinics In Perinatology 2005, 32: 523-559. PMID: 16085019, PMCID: PMC7119141, DOI: 10.1016/j.clp.2005.04.006.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesPreterm birthPregnancy outcomesLong-term neurologic damageEarly preterm birthAdverse FetalPerinatal infectionIntrauterine infectionMaternal infectionNeonatal outcomesLatter infectionNeonatal infectionNeurologic damageBacterial vaginosisOverall burdenInfectionBirthOutcomesVaginosisRubellaSyphilisFetal
2003
Role of Psychosocial and Nutritional Stress on Poor Pregnancy Outcome
Hobel C, Culhane J. Role of Psychosocial and Nutritional Stress on Poor Pregnancy Outcome. Journal Of Nutrition 2003, 133: 1709s-1717s. PMID: 12730488, DOI: 10.1093/jn/133.5.1709s.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLow birth weightPreterm birthBirth weightAge-matched control subjectsRole of PsychosocialIndependent risk factorMaternal psychosocial stressPoor pregnancy outcomesStrenuous physical activityInitiation of laborElevated corticotropin-releasing hormonePlausible biological pathwaysPreterm laborPregnancy outcomesImmunomodulatory effectsControl subjectsEpidemiological evidenceRisk factorsClinical studiesPhysical activityEpidemiological dataMaternal stressPsychosocial stressClinical programs
2001
Pennsylvania's early discharge legislation: effect on maternity and infant lengths of stay and hospital charges in Philadelphia.
Webb D, Culhane J, Snyder S, Greenspan J. Pennsylvania's early discharge legislation: effect on maternity and infant lengths of stay and hospital charges in Philadelphia. Health Services Research 2001, 36: 1073-83. PMID: 11775668, PMCID: PMC1089279.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth CertificatesCommunity Health PlanningDelivery, ObstetricFemaleHealth Care SurveysHealth Maintenance OrganizationsHospital ChargesHumansInfant, NewbornInsurance CoverageLength of StayMedical Record LinkageObstetrics and Gynecology Department, HospitalPatient DischargePhiladelphiaPostnatal CareTime FactorsConceptsHospital chargesResident live birthsLive birthsAnnual health care costsDescriptive epidemiological studyHealth care costsVaginal birthInfant costsInfant lengthSecondary data analysisEpidemiological studiesMedian chargeCare costsDischarge practicesBirth recordsResident birthsOne-year periodMaternal lengthBirthLOSMinimum LOSMothersLOS variablesData pertainingHoursStress, infection and preterm birth: a biobehavioural perspective
Wadhwa P, Culhane J, Rauh V, Barve S, Hogan V, Sandman C, Hobel C, Chicz‐DeMet A, Dunkel‐Schetter C, Garite T, Glynn L. Stress, infection and preterm birth: a biobehavioural perspective. Paediatric And Perinatal Epidemiology 2001, 15: 17-29. PMID: 11520397, DOI: 10.1046/j.1365-3016.2001.00005.x.Peer-Reviewed Original ResearchConceptsPreterm birthMaternal stressImmune processesPlacental corticotropin-releasing hormoneFetal endocrine systemObstetric risk assessmentIndependent risk factorSpontaneous preterm birthSpontaneous preterm deliveryPro-inflammatory mechanismsCorticotropin-releasing hormoneInfectious-inflammatory processMaternal-child healthUrogenital tract infectionsChronic maternal stressPreterm parturitionPreterm deliveryTract infectionsLocal immunityPregnant womenInflammatory pathwaysRisk factorsPhysiology of parturitionEpidemiological studiesPathophysiological eventsStress and Preterm Birth: Neuroendocrine, Immune/Inflammatory, and Vascular Mechanisms
Wadhwa P, Culhane J, Rauh V, Barve S. Stress and Preterm Birth: Neuroendocrine, Immune/Inflammatory, and Vascular Mechanisms. Maternal And Child Health Journal 2001, 5: 119-125. PMID: 11573837, DOI: 10.1023/a:1011353216619.Peer-Reviewed Original Research
2000
Effect of nonviable infants on the infant mortality rate in Philadelphia, 1992
Gibson E, Culhane J, Saunders T, Webb D, Greenspan J. Effect of nonviable infants on the infant mortality rate in Philadelphia, 1992. American Journal Of Public Health 2000, 90: 1303-1306. PMID: 10937015, PMCID: PMC1446342, DOI: 10.2105/ajph.90.8.1303.Peer-Reviewed Original Research
1998
Adverse neurodevelopmental outcome after extracorporeal membrane oxygenation among neonates with bronchopulmonary dysplasia
Kornhauser M, Baumgart S, Desai S, Stanley C, Culhane J, Cullen J, Wiswell T, Graziani L, Spitzer A. Adverse neurodevelopmental outcome after extracorporeal membrane oxygenation among neonates with bronchopulmonary dysplasia. The Journal Of Pediatrics 1998, 132: 307-311. PMID: 9506646, DOI: 10.1016/s0022-3476(98)70450-0.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaAdverse neurodevelopmental outcomesNeurodevelopmental outcomesMembrane oxygenationOccurrence of BPDSevere disabilityMild neurologic disabilitiesMonths 11 patientsRespiratory distress syndromeInfant Development scoresEarly Learning scoresECMO initiationECMO treatmentHospital chartsNeurologic disabilityDistress syndromeMean ageOutcome dataBPD groupLarge seriesBayley ScalesECMOInfantsPatientsMild disability