2021
A model of metabolic supply-demand mismatch leading to secondary brain injury
Song JL, Kim JA, Struck AF, Zhang R, Westover MB. A model of metabolic supply-demand mismatch leading to secondary brain injury. Journal Of Neurophysiology 2021, 126: 653-667. PMID: 34232754, PMCID: PMC8815783, DOI: 10.1152/jn.00674.2020.Peer-Reviewed Original ResearchConceptsPrimary brain injurySecondary brain injuryAcute brain injuryBrain injuryExtracellular potassiumAdditional brain injuryAssociation of seizuresIschemic strokeNeurologic insultPreventable complicationsSeizure activityCommon sequalaeTissue hypoxiaMetabolic crisisSeizuresInjuryExcitotoxicityPatientsCommon associationAssociationCurrent practiceExcitotoxityComplicationsHemorrhageIschemia
2009
Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue
Zhang J, Laiwalla F, Kim JA, Urabe H, Van Wagenen R, Song YK, Connors BW, Zhang F, Deisseroth K, Nurmikko AV. Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue. Journal Of Neural Engineering 2009, 6: 055007. PMID: 19721185, PMCID: PMC2921864, DOI: 10.1088/1741-2560/6/5/055007.Peer-Reviewed Original ResearchConceptsMillisecond temporal controlIntegrated deviceNeural activityOptical stimulationHybrid deviceArray deviceProspective clinical treatmentMouse brain slicesOptical waveguidesOptical deliveryGanglion cellsBrain slicesNeurological diseasesRecording capabilitiesMouse retinaBrain tissueClinical treatmentElectrophysiological meansStimulation siteRecording arrayLocal deliveryDevicesRetinal photoreceptorsNeuronal spiking activityStimulation