Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
Beites T, O’Brien K, Tiwari D, Engelhart C, Walters S, Andrews J, Yang H, Sutphen M, Weiner D, Dayao E, Zimmerman M, Prideaux B, Desai P, Masquelin T, Via L, Dartois V, Boshoff H, Barry C, Ehrt S, Schnappinger D. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development. Nature Communications 2019, 10: 4970. PMID: 31672993, PMCID: PMC6823465, DOI: 10.1038/s41467-019-12956-2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAntitubercular AgentsCallithrixDrug DevelopmentElectron TransportElectron Transport Complex IIIElectron Transport Complex IVGene Knockdown TechniquesImidazolesIn Vitro TechniquesLungMiceMycobacterium tuberculosisNADH DehydrogenasePiperidinesPyridinesTuberculosisTuberculosis, PulmonaryConceptsTuberculosis drug developmentDrug developmentTreatment of MtbDisease progressionMost lesionsOxidase inhibitorsClinical useType-2 NADH dehydrogenaseMycobacterium tuberculosisMiceRespiratory chainFatty acidsIntrinsic plasticityRespiratory enzymesInflammationClofazimineStandard growth mediumLesionsTuberculosis