2001
Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy.
Lee V, Rofsky N, Morgan G, Teperman L, Krinsky G, Berman P, Weinreb J. Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy. American Journal Of Roentgenology 2001, 176: 906-8. PMID: 11264075, DOI: 10.2214/ajr.176.4.1760906.Peer-Reviewed Original Research
2000
Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: Results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging
Federle M, Chezmar J, Rubin D, Weinreb J, Freeny P, Schmiedl U, Brown J, Borrello J, Lee J, Semelka R, Mattrey R, Dachman A, Saini S, Harms S, Mitchell D, Anderson M, Halford H, Bennett W, Young S, Rifkin M, Gay S, Ballerini R, Sherwin P, Robison R. Efficacy and safety of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: Results of the U.S. Multicenter phase III clinical trials. Efficacy of early imaging. Journal Of Magnetic Resonance Imaging 2000, 12: 689-701. PMID: 11050638, DOI: 10.1002/1522-2586(200011)12:5<689::aid-jmri5>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsUnenhanced magnetic resonance imagingMagnetic resonance imagingMangafodipir trisodium injectionFinal diagnosisMulticenter phase III clinical trialContrast-enhanced computed tomography examinationPhase III clinical trialsContrast-enhanced magnetic resonance imagingInjection of MnDPDPPatient's final diagnosisHepatic magnetic resonance imagingComputed tomography examinationEnhanced magnetic resonance imagingFocal liver diseaseAdditional diagnostic informationFocal liver lesionsLiver diseaseEarly imagingMRI evaluationHepatic massClinical trialsTomography examinationIntravenous administrationPatient managementRadiologic diagnosisSafety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety)
Federle M, Chezmar J, Rubin D, Weinreb J, Freeny P, Semelka R, Brown J, Borrello J, Lee J, Mattrey R, Dachman A, Saini S, Harmon B, Fenstermacher M, Pelsang R, Harms S, Mitchell D, Halford H, Anderson M, Johnson C, Francis I, Bova J, Kenney P, Klippenstein D, Foster G, Turner D, Stillman A, Nelson R, Young S, Patt R, Rifkin M, Seltzer S, Gay S, Robison R, Sherwin P, Ballerini R. Safety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety). Journal Of Magnetic Resonance Imaging 2000, 12: 186-197. PMID: 10931579, DOI: 10.1002/1522-2586(200007)12:1<186::aid-jmri21>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAgedAged, 80 and overCardiovascular DiseasesContrast MediaDiagnosis, DifferentialEdetic AcidFemaleHumansImage EnhancementInjections, IntravenousLiver CirrhosisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPainPregnancyPyridoxal PhosphateRisk AssessmentSensitivity and SpecificityVomitingConceptsMagnetic resonance imagingMangafodipir trisodium injectionAdverse eventsMulticenter phase III clinical trialContrast-enhanced computed tomography examinationPhase III clinical trialsUnenhanced magnetic resonance imagingInjection of MnDPDPInjection-associated discomfortSerious adverse eventsShort-term safetyHepatic magnetic resonance imagingComputed tomography examinationSignificant short-term riskShort-term riskFocal liver lesionsClinical trialsTomography examinationLaboratory valuesLiver lesionsResonance imagingVital signsPatientsMnDPDPInjection
1994
Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions initial findings
Birnbaum B, Weinreb J, Fernandez M, Brown J, Rofsky N, Young S. Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions initial findings. Clinical Imaging 1994, 18: 21-27. PMID: 8180855, DOI: 10.1016/0899-7071(94)90141-4.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMn-DPDPMore lesionsRetrospective multi-institutional studyExtensive metastatic diseaseHepatic magnetic resonance imagingMulti-institutional studyFocal hepatic diseaseFocal liver lesionsN'-dipyridoxylethylenediamineMetastatic diseaseIntravenous bolusDose groupFatty liverHepatic diseaseComparison of ContrastHepatic lesionsComputed tomographyLiver lesionsCT studiesPatientsMumol/Resonance imagingBolus contrastLesions
1993
Hepatocellular tumors: characterization with Mn-DPDP-enhanced MR imaging.
Rofsky N, Weinreb J, Bernardino M, Young S, Lee J, Noz M. Hepatocellular tumors: characterization with Mn-DPDP-enhanced MR imaging. Radiology 1993, 188: 53-9. PMID: 8390072, DOI: 10.1148/radiology.188.1.8390072.Peer-Reviewed Original Research
1992
Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate): clinical experience with a new contrast agent.
Rofsky N, Weinreb J. Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate): clinical experience with a new contrast agent. Magnetic Resonance Quarterly 1992, 8: 156-68. PMID: 1390058.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMn-DPDPN'-dipyridoxylethylenediamineClinical experienceNon-enhanced T1Significant adverse eventsEnhanced magnetic resonance imagingManganese NT2-weighted imagesAdverse eventsHepatocellular originClinical trialsContrast agentsHepatobiliary agentsResonance imagingLiver imagingFavorable resultsLesion detectionNew contrast agentsIssues of safetyImaging techniquesAgentsImagingOptimal methodNumerous strategiesHepatic MR imaging with Mn-DPDP: safety, image quality, and sensitivity.
Bernardino M, Young S, Lee J, Weinreb J. Hepatic MR imaging with Mn-DPDP: safety, image quality, and sensitivity. Radiology 1992, 183: 53-8. PMID: 1549694, DOI: 10.1148/radiology.183.1.1549694.Peer-Reviewed Original ResearchConceptsMn-DPDPMore lesionsAdditional lesionsT1-weighted imagesDose groupSerious side effectsMagnetic resonance imagingT2-weighted imagesFocal hepatic diseaseN'-dipyridoxylethylenediamineIntravenous bolusHepatic diseaseMultiinstitutional studyPatientsSide effectsLesionsResonance imagingHepatic MRManganese NImaging parametersContrast agentsImagingGroupInfusionBolus
1991
Contrast-Enhanced Magnetic Resonance Imaging of the Liver with Mn-DPDP for Known or Suspected Focal Hepatic Disease
BERNARDINO M, YOUNG S, LEE J, WEINREB J. Contrast-Enhanced Magnetic Resonance Imaging of the Liver with Mn-DPDP for Known or Suspected Focal Hepatic Disease. Investigative Radiology 1991, 26: s148-s149. PMID: 1808113, DOI: 10.1097/00004424-199111001-00050.Peer-Reviewed Original Research