2022
Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome
Roston TM, Wei J, Guo W, Li Y, Zhong X, Wang R, Estillore JP, Peltenburg PJ, Noguer FRI, Till J, Eckhardt LL, Orland KM, Hamilton R, LaPage MJ, Krahn AD, Tadros R, Vinocur JM, Kallas D, Franciosi S, Roberts JD, Wilde AAM, Jensen HK, Sanatani S, Chen SRW. Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome. JAMA Cardiology 2022, 7: 84-92. PMID: 34730774, PMCID: PMC8567190, DOI: 10.1001/jamacardio.2021.4458.Peer-Reviewed Original ResearchConceptsCatecholaminergic polymorphic ventricular tachycardiaExercise stress testingDeficiency syndromeRYR2 variantsVentricular tachyarrhythmiasArrhythmic eventsVentricular fibrillationLife-threatening arrhythmic eventsMulticenter observational cohort studyFunction variantsCardiac ryanodine receptor 2Complex ventricular tachyarrhythmiasPrevious arrhythmic eventsΒ-blocker therapyObservational cohort studyPolymorphic ventricular tachycardiaLife-threatening eventsSpectrum of diseaseVentricular fibrillation episodesFirst clinical seriesRyanodine receptor 2Better diagnostic toolsCohort studyVentricular arrhythmiasClinical series
2018
Mortality Following Pediatric Congenital Heart Surgery: An Analysis of the Causes of Death Derived From the National Death Index
McCracken C, Spector LG, Menk JS, Knight JH, Vinocur JM, Thomas AS, Oster ME, St Louis JD, Moller JH, Kochilas L. Mortality Following Pediatric Congenital Heart Surgery: An Analysis of the Causes of Death Derived From the National Death Index. Journal Of The American Heart Association 2018, 7: e010624. PMID: 30571499, PMCID: PMC6404427, DOI: 10.1161/jaha.118.010624.Peer-Reviewed Original ResearchConceptsCongenital heart surgeryNational Death IndexCongenital heart defectsStandardized mortality ratioCause of deathHeart surgeryDeath IndexCardiovascular disordersHeart failureSeverity of CHDCause-specific standardized mortality ratiosPediatric Cardiac Care ConsortiumRetrospective cohort studyAdjusted odds ratioLong-term outcomesRisk of deathLong-term riskConclusions SurvivorsMedian followNoncardiac conditionsCohort studyResidual morbidityEarly outcomesLate causesCardiac arrestTrends in Long-Term Mortality After Congenital Heart Surgery
Spector LG, Menk JS, Knight JH, McCracken C, Thomas AS, Vinocur JM, Oster ME, St Louis JD, Moller JH, Kochilas L. Trends in Long-Term Mortality After Congenital Heart Surgery. Journal Of The American College Of Cardiology 2018, 71: 2434-2446. PMID: 29793633, PMCID: PMC5978758, DOI: 10.1016/j.jacc.2018.03.491.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioCongenital heart surgeryLong-term mortalityHeart surgeryLong-term survivalGeneral populationOverall standardized mortality ratioSurvival of patientsLarge U.S. cohortNational Death IndexPatent ductus arteriosusPediatric cardiac surgeryAtrial septal defectForms of CHDMulticenter registryCardiac surgeryDuctus arteriosusSingle ventricleDeath IndexGreat arteriesSeptal defectMortality ratioU.S. cohortSurgerySurvival analysisOutcomes after surgical coronary artery revascularisation in children with congenital heart disease
Thammineni K, Vinocur J, Harvey B, Menk J, Kelleman M, Korakiti A, Thomas A, Moller J, St Louis J, Kochilas L. Outcomes after surgical coronary artery revascularisation in children with congenital heart disease. Heart 2018, 104: 1417. PMID: 29472291, PMCID: PMC6092219, DOI: 10.1136/heartjnl-2017-312652.Peer-Reviewed Original ResearchConceptsSurgical coronary revascularisationCongenital heart diseaseTransplant-free survivalCoronary revascularisationHeart diseaseLong-term transplant-free survivalUS National Death IndexPediatric Cardiac Care ConsortiumRetrospective cohort studyCoronary artery revascularisationNational Death IndexLong-term outcomesGraft patency dataLong-term survivalCoronary anomaliesHospital mortalityMulticentre registryBypass GraftingHospital deathCohort studyHospital dischargePatency dataDeath IndexAortic rootRevascularisation
2017
Long-Term Transplant-Free Survival After Repair of Total Anomalous Pulmonary Venous Connection
St. Louis J, McCracken C, Turk E, Hancock H, Menk J, Harvey B, Vinocur J, Oster M, Moller J, Spector L, Kochilas L. Long-Term Transplant-Free Survival After Repair of Total Anomalous Pulmonary Venous Connection. The Annals Of Thoracic Surgery 2017, 105: 186-192. PMID: 28847536, PMCID: PMC5729081, DOI: 10.1016/j.athoracsur.2017.05.052.Peer-Reviewed Original ResearchConceptsTotal anomalous pulmonary venous connectionTransplant-free survivalAnomalous pulmonary venous connectionPediatric Cardiac Care ConsortiumPulmonary venous connectionNational Death IndexLong-term outcomesTAPVC repairPostoperative lengthVenous connectionCardiac lesionsDeath IndexUnited NetworkOrgan SharingCare ConsortiumRepair of TAPVCLong-term transplant-free survivalWorse long-term outcomesBilateral lung transplantationDeath/transplantRisks of transplantationRisk of mortalityTime of procedureMajority of deathsCause of deathThe clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry
Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry. EP Europace 2017, 20: 541-547. PMID: 28158428, PMCID: PMC6059141, DOI: 10.1093/europace/euw389.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCalsequestrinChildDeath, Sudden, CardiacDNA Mutational AnalysisFemaleGenetic MarkersGenetic Predisposition to DiseaseHeredityHumansMaleModels, MolecularMutationPedigreePhenotypePrognosisProtein ConformationRegistriesRetrospective StudiesRisk FactorsRyanodine Receptor Calcium Release ChannelStructure-Activity RelationshipTachycardia, VentricularConceptsCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaCardiac eventsCPVT patientsVentricular tachycardiaLife-threatening cardiac eventsInternational multicentre registrySevere CPVT phenotypeRetrospective cohort studyFirst-degree relativesYears of ageRyanodine receptor 2CPVT phenotypeMulticentre registryCohort studySymptomatic patientsMulticentre studyVentricular arrhythmiasCardiac arrestPrognostic markerReceptor 2Ion channelopathiesClinical phenotypeGenetic spectrumGenotypic spectrumCongenital Diaphragmatic Hernia with Liver Herniation into the Pericardial Sac in a 30-Week Gestation Infant
Patel N, Sollinger C, D’Angio C, Vinocur JM, Ackerman KG, Katzman PJ. Congenital Diaphragmatic Hernia with Liver Herniation into the Pericardial Sac in a 30-Week Gestation Infant. Pediatric And Developmental Pathology 2017, 20: 421-425. PMID: 28812464, DOI: 10.1177/1093526616686446.Peer-Reviewed Case Reports and Technical NotesConceptsLiver herniationDiaphragmatic defectPericardial tumorPericardial sacAnterior diaphragmatic defectSubset of patientsCongenital diaphragmatic herniaAtrioventricular septal defectPentalogy of CantrellMultiple congenital anomaliesComplex of syndromesPericardial involvementGestation infantsDiaphragmatic herniaSeptal defectUnusual presentationAssociated anomaliesEarly recognitionPostmortem studiesCongenital anomaliesChallenging entityPrenatal ultrasoundHerniationPentalogyTumors
2016
In‐Hospital Vital Status and Heart Transplants After Intervention for Congenital Heart Disease in the Pediatric Cardiac Care Consortium: Completeness of Ascertainment Using the National Death Index and United Network for Organ Sharing Datasets
Spector L, Menk J, Vinocur J, Oster M, Harvey B, St. Louis J, Moller J, Kochilas L. In‐Hospital Vital Status and Heart Transplants After Intervention for Congenital Heart Disease in the Pediatric Cardiac Care Consortium: Completeness of Ascertainment Using the National Death Index and United Network for Organ Sharing Datasets. Journal Of The American Heart Association 2016, 5: e003783. PMID: 27506544, PMCID: PMC5015299, DOI: 10.1161/jaha.116.003783.Peer-Reviewed Original ResearchConceptsPediatric Cardiac Care ConsortiumNational Death IndexCongenital heart diseaseOrgan Sharing datasetHeart transplantUNOS registryDeath IndexUnited NetworkHeart diseaseCare ConsortiumLong-term deathLong-term outcomesCompleteness of ascertainmentHospital deathTransplant statusVital statusNational registryCase ascertainmentCardiovascular conditionsTransplant eventsTransplantYears postinterventionRegistryDeathPatientsFactors Affecting Length of Postoperative Hospitalization for Pediatric Cardiac Operations in a Large North American Registry (1982–2007)
al-Haddad BJ, Menk JS, Kochilas L, Vinocur JM. Factors Affecting Length of Postoperative Hospitalization for Pediatric Cardiac Operations in a Large North American Registry (1982–2007). Pediatric Cardiology 2016, 37: 884-891. PMID: 26965705, PMCID: PMC5724563, DOI: 10.1007/s00246-016-1364-0.Peer-Reviewed Original ResearchConceptsPostoperative hospitalizationSurgical volumeAnnual surgical volumeHealthcare resource useLow-volume centersPediatric cardiac operationsFactors Affecting LengthCongenital heart diseaseNorth American RegistrySurgical treatmentEarly dischargeCardiac operationsPediatric hospitalizationsVolume centersHeart diseaseClinical significanceMerit further investigationSex-specific differencesHospitalizationEfficient careMajor causeRisk adjustmentOlder childrenTime interactionRandom effects
2015
Catecholaminergic Polymorphic Ventricular Tachycardia in Children
Roston TM, Vinocur JM, Maginot KR, Mohammed S, Salerno JC, Etheridge SP, Cohen M, Hamilton RM, Pflaumer A, Kanter RJ, Potts JE, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Kannankeril PJ, Sanatani S. Catecholaminergic Polymorphic Ventricular Tachycardia in Children. Circulation Arrhythmia And Electrophysiology 2015, 8: 633-642. PMID: 25713214, PMCID: PMC4472494, DOI: 10.1161/circep.114.002217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnti-Arrhythmia AgentsChildDeath, Sudden, CardiacDefibrillators, ImplantableElectric CountershockFemaleHumansMalePatient SelectionPhenotypeRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexSympathectomyTachycardia, VentricularTime FactorsTreatment OutcomeConceptsCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaCardiac sympathetic denervationImplantable cardioverter defibrillatorVentricular tachycardiaSympathetic denervationTreatment failureCardioverter defibrillatorΒ-blockersCatecholaminergic polymorphic ventricular tachycardia patientsQuarter of patientsRetrospective cohort studyDevice-related complicationsTreatment failure eventsYears of ageVentricular tachycardia patientsCohort studyStandard therapySymptom onsetSymptomatic presentationCardiac arrestSubtherapeutic dosingTreatment outcomesElectrical stormTachycardia patients
2014
Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery
Kochilas LK, Vinocur JM, Menk JS. Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery. Journal Of The American Heart Association 2014, 3: e000608. PMID: 24496232, PMCID: PMC3959673, DOI: 10.1161/jaha.113.000608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCardiac Surgical ProceduresChildChild, PreschoolChi-Square DistributionFemaleHealth Status DisparitiesHeart Defects, CongenitalHospital MortalityHumansInfantInfant, NewbornLogistic ModelsMaleMultivariate AnalysisNorth AmericaOdds RatioRegistriesRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeConceptsPediatric cardiac operationsPediatric cardiac surgeryCardiac surgeryCardiac operationsPostsurgical mortalityHigh-risk cardiac operationsPediatric Cardiac Care ConsortiumRisk of deathMonths of lifePotential sex differencesAge-dependent relationshipSurgical yearHospital mortalityUnadjusted mortalityPatient sexWhole cohortHigh-risk operationsCardiovascular diseaseSex effectsCardiovascular stressCare ConsortiumEarly infancyZ-scoreLogistic regressionMortality
2013
Two-ventricle repairs in the unbalanced atrioventricular canal defect spectrum with midterm follow-up
Foker J, Berry J, Vinocur J, Harvey B, Pyles L. Two-ventricle repairs in the unbalanced atrioventricular canal defect spectrum with midterm follow-up. Journal Of Thoracic And Cardiovascular Surgery 2013, 146: 854-860.e3. PMID: 23871139, DOI: 10.1016/j.jtcvs.2013.05.013.Peer-Reviewed Original ResearchAbnormalities, MultipleAdolescentAdultCardiac Surgical ProceduresChildChild, PreschoolEndocardial Cushion DefectsFemaleHeart Septal DefectsHeart Septal Defects, AtrialHeart Septal Defects, VentricularHeart VentriclesHumansInfantInfant, NewbornMaleTime FactorsTreatment OutcomeUltrasonographyYoung AdultFrequency of Superior Vena Cava Obstruction in Pediatric Heart Transplant Recipients and Its Relation to Previous Superior Cavopulmonary Anastomosis
Aldoss O, Arain NI, Vinocur JM, Menk J, Ameduri RK, Bryant R, Kochilas LK, Gruenstein DH. Frequency of Superior Vena Cava Obstruction in Pediatric Heart Transplant Recipients and Its Relation to Previous Superior Cavopulmonary Anastomosis. The American Journal Of Cardiology 2013, 112: 286-291. PMID: 23587279, PMCID: PMC6118126, DOI: 10.1016/j.amjcard.2013.03.029.Peer-Reviewed Original ResearchConceptsOrthotopic heart transplantationSuperior vena cava obstructionSVC obstructionVena cava obstructionCavopulmonary anastomosisSuperior cavopulmonary anastomosisCardiac surgeryCava obstructionRisk factorsPediatric heart transplant recipientsPediatric orthotopic heart transplantationSubsequent orthotopic heart transplantationPediatric OHT patientsHeart transplant recipientsPrevious cardiac surgerySignificant risk factorsOHT patientsPosttransplant developmentHeart transplantationTransplant recipientsRetrospective reviewPatientsObstructionSurgeryTransplantationSurgical Volume and Center Effects on Early Mortality After Pediatric Cardiac Surgery: 25-Year North American Experience From a Multi-institutional Registry
Vinocur JM, Menk JS, Connett J, Moller JH, Kochilas LK. Surgical Volume and Center Effects on Early Mortality After Pediatric Cardiac Surgery: 25-Year North American Experience From a Multi-institutional Registry. Pediatric Cardiology 2013, 34: 1226-1236. PMID: 23377381, PMCID: PMC4357309, DOI: 10.1007/s00246-013-0633-4.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgerySurgical volumePostoperative mortalityCardiac surgeryOdds ratioCenter effectVolume categoriesHierarchical multivariate logistic regression analysisMultivariate logistic regression analysisPediatric Cardiac Care ConsortiumRisk categoriesStudy periodCenter-specific variationCentres' surgical volumeRisk Adjusted ClassificationRetrospective cohort studyEarly postoperative mortalityMulti-institutional registryOdds of deathCongenital heart surgeryNorth American centersLogistic regression analysisLow-risk operationCohort studyPatient characteristics
2010
Fetal Goiter Mimicking Anomalous Pulmonary Venous Connection
Vinocur JM, Sivanandam S. Fetal Goiter Mimicking Anomalous Pulmonary Venous Connection. Congenital Heart Disease 2010, 5: 482-485. PMID: 21087438, DOI: 10.1111/j.1747-0803.2010.00392.x.Peer-Reviewed Case Reports and Technical NotesConceptsAnomalous pulmonary venous connectionPulmonary venous connectionVenous connectionFetal goiterFetal thyroid dysfunctionSecondary cardiac diseaseStructural heart diseaseThyroid dysfunctionHeart diseasePediatric cardiologistsCardiac diseaseHydrops fetalisGoiterDiseaseDysfunctionArrhythmiasFetalisCardiologists
2003
LETAL, A Tumor-Associated NKG2D Immunoreceptor Ligand, Induces Activation and Expansion of Effector Immune Cells
Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, Coukos G. LETAL, A Tumor-Associated NKG2D Immunoreceptor Ligand, Induces Activation and Expansion of Effector Immune Cells. Cancer Biology & Therapy 2003, 2: 446-451. PMID: 14508119, DOI: 10.4161/cbt.2.4.479.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisCD8-Positive T-LymphocytesColonic NeoplasmsCytotoxicity, ImmunologicFemaleHumansImmunoglobulin GInterferon-gammaInterleukin-2K562 CellsKiller Cells, NaturalLigandsLymphocyte ActivationMiceMice, Inbred C57BLMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KOvarian NeoplasmsReceptors, Antigen, T-CellReceptors, ImmunologicReceptors, Natural Killer CellRNA, MessengerSequence Homology, Amino AcidTretinoinType C PhospholipasesConceptsNK cellsNKG2D ligandsTumor cellsTumor immune surveillanceEffector immune cellsPotent activating receptorT cell receptor activationIFNgamma secretionEffector lymphocytesActivating receptorsIL-2Immune cellsImmune surveillancePeripheral tissuesCytotoxic lymphocytesReceptor activationMRNA expressionNormal tissuesCancer cellsRetinoic acidInduces activationLymphocytesCellsTissueActivation