2014
The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes
Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. Journal Of Cell Science 2014, 127: 4381-4395. PMID: 25179599, PMCID: PMC4197085, DOI: 10.1242/jcs.146217.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonActinsAdaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCarrier ProteinsCell MovementCell PolarityCells, CulturedLeukocytesMicrotubule-Organizing CenterMultiprotein ComplexesMutationOryziasProtein Kinase CProtein TransportRho-Associated KinasesZebrafishZebrafish ProteinsConceptsAtypical protein kinase CMicrotubule organizing centerPAR-6Par complexPAR-3Protein kinase CRegulated interactionFish larvaeMyeloid cellsGenetic manipulationPolarizing cuesKinase activationCytoskeletal changesF-actinKinase COrganizing centerFunctional polarizationRho kinase activationThree-dimensional environmentTraction forceCellsSpatiotemporal dynamicsLeukocyte migrationMigrationComplexes
2006
Pathophysiology of leukocyte–tissue interactions
Molteni R, Fabbri M, Bender JR, Pardi R. Pathophysiology of leukocyte–tissue interactions. Current Opinion In Cell Biology 2006, 18: 491-498. PMID: 16904306, DOI: 10.1016/j.ceb.2006.08.001.Peer-Reviewed Original Research
2002
Integrin‐dependent regulation of gene expression in leukocytes
Rossetti G, Collinge M, Molteni R, Bender J, Pardi R. Integrin‐dependent regulation of gene expression in leukocytes. Immunological Reviews 2002, 186: 189-207. PMID: 12234372, DOI: 10.1034/j.1600-065x.2002.18616.x.Peer-Reviewed Original ResearchConceptsIntegrin engagementGene expression regulationIntegrin-dependent regulationCell cycle restriction pointExpression regulationNumerous genesTransduce signalsMatrix degrading proteinsTranscriptional activationGenetic programTranscription modulatorsIntegrin-dependent mechanismJAK-STATsGene expressionIntercellular adhesionDegrading proteinsCell differentiationAlphaLbeta2 integrinJab-1Restriction pointMRNA transcriptsT cell differentiationEnvironmental stimuliPotent signalCell phenotype
1998
Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement
Wang G, Collinge M, Blasi F, Pardi R, Bender J. Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6296-6301. PMID: 9600959, PMCID: PMC27663, DOI: 10.1073/pnas.95.11.6296.Peer-Reviewed Original ResearchConceptsAU-rich elementsLFA-1 activationMRNA degradationReporter constructsUrokinase plasminogen activator receptorT cell activationCrucial cis-acting elementsCis-acting elementsLymphocyte function-associated antigen-1Integrin lymphocyte function-associated antigen-1Jurkat T cellsLFA-1 engagementUPAR cDNAReceptor-mediated signalingPosttranscriptional regulationTransmembrane signalingReporter mRNAIntegrin engagementCell activationInhibitor 5Adhesion receptorsSecond messengerMessenger RNA levelsPlasminogen activator receptorFunction-associated antigen-1
1997
Through and beyond the wall: late steps in leukocyte transendothelial migration
Bianchi E, Bender J, Blasi F, Pardi R. Through and beyond the wall: late steps in leukocyte transendothelial migration. Trends In Immunology 1997, 18: 586-591. PMID: 9425737, DOI: 10.1016/s0167-5699(97)01162-6.Peer-Reviewed Original Research
1992
Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers
Pardi R, Inverardi L, Bender J. Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers. Trends In Immunology 1992, 13: 224-230. PMID: 1304726, DOI: 10.1016/0167-5699(92)90159-5.Peer-Reviewed Original Research