2000
Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein
Sadeghi M, Collinge M, Pardi R, Bender J. Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein. The Journal Of Immunology 2000, 165: 2712-2718. PMID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicBiological TransportCell Adhesion MoleculesCells, CulturedCholesterolCytokinesDrug SynergismE-SelectinEndothelium, VascularGene Expression RegulationGTP-Binding Protein alpha Subunits, Gi-GoHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntercellular Adhesion Molecule-1Interleukin-1NF-kappa BRNA, MessengerSignal TransductionSimvastatinSodium FluorideUmbilical VeinsVascular Cell Adhesion Molecule-1ConceptsEffect of simvastatinCytokine-induced expressionIL-1Endothelial CAMsEndothelial cell adhesion molecules E-selectinNF-kappaBProinflammatory cytokines IL-1Cell adhesion molecules E-selectinAdhesion molecules E-selectinPotent immune modulatorG protein activator NaFCytokines IL-1G protein-coupled pathwayInhibitory G proteinCytokine-mediated activationSelectin mRNA levelsBasal toneProinflammatory cytokinesGialpha proteinsImmune modulatorsTNF-alphaICAM-1Pertussis toxinE-selectinEndothelial response
1998
Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.
Cuff C, Schwartz J, Bergman C, Russell K, Bender J, Ruddle N. Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development. The Journal Of Immunology 1998, 161: 6853-60. PMID: 9862717, DOI: 10.4049/jimmunol.161.12.6853.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesChemokine CCL2Chemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL2ChemokinesChemokines, CXCCytotoxicity, ImmunologicEmbryonic and Fetal DevelopmentE-SelectinGene Expression RegulationHumansImmunoglobulinsInflammationIntercellular Adhesion Molecule-1Lymphoid TissueLymphotoxin-alphaMacrophage Inflammatory ProteinsMiceMonokinesMucoproteinsRecombinant Fusion ProteinsSpecies SpecificityStimulation, ChemicalTumor Cells, CulturedVascular Cell Adhesion Molecule-1ConceptsLymphoid organ developmentMAdCAM-1LT-alphaLT alpha3Adhesion moleculesTreatment periodIFN-inducible protein-10Biologic activityInduction of chemokinesChemotactic protein-1Peripheral node addressinCellular adhesion moleculesMucosal addressin MAdCAM-1Unique biologic activityInflammatory mediatorsChemokine expressionProinflammatory effectsLymphoid tissueMTNF-alphaMaximal killingChemokine RANTESE-selectinKnockout miceProtein 10Alpha preparationsModulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
Caulin-Glaser T, Farrell W, Pfau S, Zaret B, Bunger K, Setaro J, Brennan J, Bender J, Cleman M, Cabin H, Remetz M. Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1555-1560. PMID: 9626834, DOI: 10.1016/s0735-1097(98)00145-4.Peer-Reviewed Original ResearchConceptsE2 replacement therapyCoronary artery diseaseVascular cell adhesion molecule-1Cellular adhesion moleculesPostmenopausal womenAdhesion molecule-1Premenopausal womenArtery diseaseCardioprotective effectsInflammatory responseAdhesion moleculesMolecule-1Incidence of CADControl groupInflammatory cytokine-induced expressionIntercellular adhesion molecule-1Expression of CAMsCell adhesion molecule-1Consecutive eligible subjectsAssociation of estrogenEndothelial cell activationCytokine-induced expressionFemale control groupSignificant increaseEnzyme-linked immunoabsorbant assay
1996
Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation.
Ferrero E, Villa A, Ferrero M, Toninelli E, Bender J, Pardi R, Zocchi M. Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation. Cancer Research 1996, 56: 3211-5. PMID: 8764109.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAntigens, Differentiation, MyelomonocyticBenzoquinonesCapillary PermeabilityCell Adhesion MoleculesCell CompartmentationCells, CulturedEndothelium, VascularEnzyme InhibitorsFluorescent Antibody Technique, IndirectGene ExpressionHumansLactams, MacrocyclicPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Kinase InhibitorsQuinonesRifabutinRNA, MessengerStaurosporineTumor Necrosis Factor-alphaUmbilical VeinsConceptsVascular leakageEndothelial cellsNecrosis factor alphaTyrosine kinase inhibitorsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsNatural tyrosine kinase inhibitorSerine-threonine kinaseVein endothelial cellsSurface redistributionFactor alphaVascular permeabilityVivo administrationKinase inhibitorsCytoskeletal associationMouse liverLavendustin AUse of inhibitorsPhosphorylationInhibitorsEffects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
Caulin-Glaser T, Watson C, Pardi R, Bender J. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. Journal Of Clinical Investigation 1996, 98: 36-42. PMID: 8690801, PMCID: PMC507398, DOI: 10.1172/jci118774.Peer-Reviewed Original ResearchConceptsCultured human umbilical vein ECEndothelial cell adhesion molecule expressionVascular cell adhesion molecule-1 inductionEstrogen receptor-mediated effectsCardiovascular protective roleCell adhesion molecule expressionAge-matched malesIncidence of atherosclerosisReceptor-mediated effectsAdhesion molecule expressionEndothelial cell activationHuman umbilical vein ECSimilar risk profilesSelectin mRNA levelsIL-1 activationPremenopausal womenAntagonist ICIMolecule expressionMononuclear leukocytesE-selectinChemotactic factorsCytokines resultsProtective roleCell activationLeukocyte adhesion
1994
Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.
Bender JR, Sadeghi MM, Watson C, Pfau S, Pardi R. Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3994-3998. PMID: 7513430, PMCID: PMC43709, DOI: 10.1073/pnas.91.9.3994.Peer-Reviewed Original Research
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammation
1992
Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers
Pardi R, Inverardi L, Bender J. Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers. Trends In Immunology 1992, 13: 224-230. PMID: 1304726, DOI: 10.1016/0167-5699(92)90159-5.Peer-Reviewed Original Research