2016
The molecular actions of oestrogen in the regulation of vascular health
Usselman CW, Stachenfeld NS, Bender JR. The molecular actions of oestrogen in the regulation of vascular health. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2016, 101: 356-361. PMID: 26778523, PMCID: PMC4947570, DOI: 10.1113/ep085148.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAction of estrogenVascular healthFunctional outcomeHormone therapy trialsNormal endothelial functionVascular smooth muscleMembrane-bound estrogen receptorMolecular actionsPremenopausal womenEndothelial functionEstrogen actionCardiovascular diseaseEstrogen receptorSmooth muscleBeneficial actionsTherapy trialsEstrogenExperimental animalsVascular structuresFindings of studiesVasculatureWomenHealthMolecular mechanismsOutcomes
2002
Rapid vascular cell responses to estrogen and membrane receptors
Haynes MP, Li L, Russell KS, Bender JR. Rapid vascular cell responses to estrogen and membrane receptors. Vascular Pharmacology 2002, 38: 99-108. PMID: 12379956, DOI: 10.1016/s0306-3623(02)00133-7.Peer-Reviewed Original ResearchConceptsSignal transduction cascadeTransduction cascadeG protein-coupled receptorsMembrane-localized estrogen receptorsEstrogen receptorTranscription factorsMAP kinaseApparent coronary heart diseaseRapid consequencesCellular responsesCellular localizationMembrane receptorsCoronary heart diseaseAge-matched malesEffects of estrogenVascular cell responsesSmooth muscle cellsVariety of estrogenVascular cellsMuscle cellsComplex formationPremenopausal womenHeart diseaseVascular wallMarked gender differences
1998
Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
Caulin-Glaser T, Farrell W, Pfau S, Zaret B, Bunger K, Setaro J, Brennan J, Bender J, Cleman M, Cabin H, Remetz M. Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1555-1560. PMID: 9626834, DOI: 10.1016/s0735-1097(98)00145-4.Peer-Reviewed Original ResearchConceptsE2 replacement therapyCoronary artery diseaseVascular cell adhesion molecule-1Cellular adhesion moleculesPostmenopausal womenAdhesion molecule-1Premenopausal womenArtery diseaseCardioprotective effectsInflammatory responseAdhesion moleculesMolecule-1Incidence of CADControl groupInflammatory cytokine-induced expressionIntercellular adhesion molecule-1Expression of CAMsCell adhesion molecule-1Consecutive eligible subjectsAssociation of estrogenEndothelial cell activationCytokine-induced expressionFemale control groupSignificant increaseEnzyme-linked immunoabsorbant assay
1996
Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
Caulin-Glaser T, Watson C, Pardi R, Bender J. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. Journal Of Clinical Investigation 1996, 98: 36-42. PMID: 8690801, PMCID: PMC507398, DOI: 10.1172/jci118774.Peer-Reviewed Original ResearchConceptsCultured human umbilical vein ECEndothelial cell adhesion molecule expressionVascular cell adhesion molecule-1 inductionEstrogen receptor-mediated effectsCardiovascular protective roleCell adhesion molecule expressionAge-matched malesIncidence of atherosclerosisReceptor-mediated effectsAdhesion molecule expressionEndothelial cell activationHuman umbilical vein ECSimilar risk profilesSelectin mRNA levelsIL-1 activationPremenopausal womenAntagonist ICIMolecule expressionMononuclear leukocytesE-selectinChemotactic factorsCytokines resultsProtective roleCell activationLeukocyte adhesion