2008
Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development
Panattoni M, Sanvito F, Basso V, Doglioni C, Casorati G, Montini E, Bender JR, Mondino A, Pardi R. Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development. Journal Of Experimental Medicine 2008, 205: 465-477. PMID: 18268034, PMCID: PMC2271025, DOI: 10.1084/jem.20070725.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-X ProteinCell CycleCell LineCell ProliferationCOP9 Signalosome ComplexCyclin-Dependent Kinase Inhibitor p16DNA RepairFemaleHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesNF-kappa BPeptide HydrolasesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellRNA, MessengerT-LymphocytesTumor Suppressor Protein p53Ubiquitin-Protein LigasesConceptsCOP9 signalosomeCSN5/Jab1Genetic programBcl-2 family membersGenetic complementation analysisBcl-xL/BclS-phase progressionDistinct developmental stagesCell cycle progressionT cell developmentComplementation analysisLower organismsCatalytic subunitPositive selectionTranscription factorsDNA repairCycle progressionCell developmentThymocyte survivalDevelopmental stagesNF-kappaB pathwayTransgenic backgroundPhase progressionRapid turnoverEffector molecules
1999
Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.
Geginat J, Bossi G, Bender J, Pardi R. Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes. The Journal Of Immunology 1999, 162: 5085-93. PMID: 10227977, DOI: 10.4049/jimmunol.162.9.5085.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCalcium-Calmodulin-Dependent Protein KinasesCell AdhesionCell CycleCell Cycle ProteinsCell SizeCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDown-RegulationEnzyme ActivationG1 PhaseGene Expression RegulationGenes, fosGenes, junHumansInterleukin-2InterphaseKineticsLymphocyte Function-Associated Antigen-1Microtubule-Associated ProteinsMitogensProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, Antigen, T-CellS PhaseT-LymphocytesTumor Suppressor ProteinsConceptsNormal T cellsT lymphocytesT cellsPrimary T lymphocytesRetinoblastoma protein inactivationCytokines IL-2Function-blocking mAbsIL-2ICAM-1Mitogen-activated protein kinase activationCyclin-dependent kinase inhibitor p27kipIntegrins actMitogenic responseMitogenic cytokinesGrowth factorLymphocytesCell cycle progressionTCR stimulationLate componentsProtein kinase activationLeukocyte integrinsAnchorage dependenceTCR triggeringCycle progressionCellular requirements