1998
Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve
Yee J, Agulian S, Kocsis J. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy Research 1998, 29: 195-200. PMID: 9551781, DOI: 10.1016/s0920-1211(97)00086-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnticonvulsantsAstrocytesAxonsBicucullineCarrier ProteinsGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane PotentialsMembrane ProteinsMembrane Transport ProteinsModels, NeurologicalNipecotic AcidsOptic NerveOrganic Anion TransportersPotassium ChlorideProlineRatsRats, WistarReceptors, GABA-ATime FactorsVigabatrinConceptsRelease of GABAGABA levelsNipecotic acidNeonatal rat optic nerveGABA transporter inhibitorOptic nerve axonsRat optic nerveOptic nerve astrocytesEnzyme GABA transaminaseGABA transaminase activityFree GABA levelsOptic nerveAntiepileptic drugsNO-711GABA transporterNerve axonsTransaminase activityGABA transaminaseVigabatrinTransporter inhibitorsGABADepolarizationGreater releaseElevationRelease
1997
Differential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons
Oyelese A, Rizzo M, Waxman S, Kocsis J. Differential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 1997, 78: 31-42. PMID: 9242258, PMCID: PMC2605357, DOI: 10.1152/jn.1997.78.1.31.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorCutaneous afferent neuronsNerve growth factorReceptor-mediated conductanceProportion of neuronsAfferent neuronsAction potential waveformSodium currentNeurotrophic factorL4/L5 DRG neuronsAction potentialsVoltage-dependent sodium currentsWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCell patch-clamp techniqueAxotomy-induced increaseFluoro-Gold injectionsL5 DRG neuronsSpecific neurotrophic factorsSciatic nerve stumpsTTX-sensitive currentsInjury-induced changesResistant sodium currentsGamma-aminobutyric acidPatch-clamp technique
1996
GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury
Oyelese A, Kocsis J. GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury. Journal Of Neurophysiology 1996, 76: 2383-2392. PMID: 8899611, PMCID: PMC2605353, DOI: 10.1152/jn.1996.76.4.2383.Peer-Reviewed Original ResearchConceptsGABAA receptor-mediated conductanceMuscle afferent neuronsCutaneous afferent neuronsAction potential waveformAfferent neuronsDorsal root gangliaCrush injuryAction potentialsL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsInjury-induced plasticitySciatic nerve ligationPotential waveformDistal nerve stumpPatch-clamp recordingsGamma-aminobutyric acidPeak GABANerve ligationMuscle afferentsNerve injuryDRG neuronsInjured neuronsNerve stumpRoot ganglia
1995
Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons
Oyelese A, Eng D, Richerson G, Kocsis J. Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons. Journal Of Neurophysiology 1995, 74: 673-683. PMID: 7472373, PMCID: PMC2605359, DOI: 10.1152/jn.1995.74.2.673.Peer-Reviewed Original ResearchConceptsDRG neuronsAction potential durationMedium neuronsNerve injurySmall neuronsLarge neuronsAction potentialsGABA conductanceNerve ligationControl neuronsPotential durationAdult rat dorsal root ganglion neuronsGABAA receptor-mediated conductanceRat dorsal root ganglion neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion neuronsMean action potential durationShort-duration action potentialsControl DRG neuronsSciatic nerve ligationEffects of axotomyReceptor-mediated conductanceTraumatic nerve injuryPatch-clamp recordings
1994
Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve
Kocsis J, Honmou O. Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neuroscience Letters 1994, 169: 181-184. PMID: 8047279, DOI: 10.1016/0304-3940(94)90386-7.Peer-Reviewed Original Research
1993
Transient presence of GABA in astrocytes of the developing optic nerve
Ochi S, Lim J, Rand M, During M, Sakatani K, Kocsis J. Transient presence of GABA in astrocytes of the developing optic nerve. Glia 1993, 9: 188-198. PMID: 8294149, DOI: 10.1002/glia.440090304.Peer-Reviewed Original ResearchConceptsWhole optic nerveOptic nerveHigh-pressure liquid chromatographyGABA immunoreactivityPostnatal developmentEnzyme glutamic acid decarboxylaseIntact optic nerveRat optic nerveNeonatal optic nerveGlutamic acid decarboxylaseAstrocyte cell bodiesPostnatal day 20GABA immunostainingGFAP stainingPostnatal weekGABA stainingNerveCultured astrocytesAstrocytesDay 20GABAAcid decarboxylaseCell bodiesDevelopmental time courseImmunoreactivityThe attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve
Lim J, Utzschneider D, Sakatani K, Kocsis J. The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve. Brain Research 1993, 72: 15-20. PMID: 8384095, DOI: 10.1016/0165-3806(93)90155-4.Peer-Reviewed Original ResearchConceptsOptic nerveRat optic nerveEffect of GABAMD ratsNipecotic acidGABA sensitivityGABA uptake inhibitor nipecotic acidNormal optic nervesGABAA receptor agonistOptic nerve axonsEarly postnatal periodCentral nervous system axonsThird postnatal weekSucrose gap techniqueResult of myelinationLarger GABAAxonal excitabilityControl ratsGABAA receptorsEndogenous releasePostnatal periodPostnatal weekNerve sensitivityNerveGABA
1992
Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve
Sakatani K, Black J, Kocsis J. Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve. Proceedings Of The Royal Society B 1992, 247: 155-161. PMID: 1349183, DOI: 10.1098/rspb.1992.0022.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveCentral nervous systemGABAA receptorsIntact rat optic nerveCultured glia cellsFunctional GABAA receptorsGABAA receptor agonistNeonatal optic nerveNeuronal cell bodiesO-2A progenitor cellsNon-synaptic sitesPre-myelinated axonsWhite matter regionsSynthesis of GABAAxonal excitabilityReceptor agonistEndogenous GABAGABA uptakeGlia cellsSynaptic neurotransmittersNervous systemEndogenous neurotransmittersType 2Nerve
1990
Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons
Bhisitkul R, Kocsis J, Gordon T, Waxman S. Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons. Experimental Neurology 1990, 109: 273-278. PMID: 2170161, DOI: 10.1016/s0014-4886(05)80017-2.Peer-Reviewed Original ResearchConceptsDistal nerve segmentsGamma-aminobutyric acidNerve segmentsSciatic nerveReceptor expressionSensory neuronsTrophic supportGABAA receptor agonist muscimolDorsal root ganglion neuronsAxotomized sensory neuronsReactive Schwann cellsGABAA receptor expressionAdult sensory neuronsReceptor agonist muscimolExpression of receptorsPeripheral target tissuesGABA receptor expressionDorsal root fibersGABA receptor sensitivityEnd organ innervationPostoperative dayNerve crushNerve transectionCrush siteDistal stump
1987
Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve
Bhisitkul R, Villa J, Kocsis J. Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Experimental Brain Research 1987, 66: 659-663. PMID: 3038587, DOI: 10.1007/bf00270698.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidVentral root fibersGABA receptorsRoot fibersSensory fibersPeripheral nervesSensory axonsRegenerated sensory axonsSucrose gap chamberPeripheral nerve fibersRat peripheral nerveDorsal root fibersMammalian peripheral nervesAgonist baclofenNerve crushDorsal rootsAgonist muscimolSciatic nerveNerve fibersRat peripheral nerve fibersNerveReceptorsMuscimolSelective presenceAxons