1997
Differential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons
Oyelese A, Rizzo M, Waxman S, Kocsis J. Differential Effects of NGF and BDNF on Axotomy-Induced Changes in GABAA-Receptor-Mediated Conductance and Sodium Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 1997, 78: 31-42. PMID: 9242258, PMCID: PMC2605357, DOI: 10.1152/jn.1997.78.1.31.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorCutaneous afferent neuronsNerve growth factorReceptor-mediated conductanceProportion of neuronsAfferent neuronsAction potential waveformSodium currentNeurotrophic factorL4/L5 DRG neuronsAction potentialsVoltage-dependent sodium currentsWhole-cell patch-clamp techniqueDorsal root ganglion neuronsCell patch-clamp techniqueAxotomy-induced increaseFluoro-Gold injectionsL5 DRG neuronsSpecific neurotrophic factorsSciatic nerve stumpsTTX-sensitive currentsInjury-induced changesResistant sodium currentsGamma-aminobutyric acidPatch-clamp technique
1996
GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury
Oyelese A, Kocsis J. GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury. Journal Of Neurophysiology 1996, 76: 2383-2392. PMID: 8899611, PMCID: PMC2605353, DOI: 10.1152/jn.1996.76.4.2383.Peer-Reviewed Original ResearchConceptsGABAA receptor-mediated conductanceMuscle afferent neuronsCutaneous afferent neuronsAction potential waveformAfferent neuronsDorsal root gangliaCrush injuryAction potentialsL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsInjury-induced plasticitySciatic nerve ligationPotential waveformDistal nerve stumpPatch-clamp recordingsGamma-aminobutyric acidPeak GABANerve ligationMuscle afferentsNerve injuryDRG neuronsInjured neuronsNerve stumpRoot ganglia
1990
Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons
Bhisitkul R, Kocsis J, Gordon T, Waxman S. Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons. Experimental Neurology 1990, 109: 273-278. PMID: 2170161, DOI: 10.1016/s0014-4886(05)80017-2.Peer-Reviewed Original ResearchConceptsDistal nerve segmentsGamma-aminobutyric acidNerve segmentsSciatic nerveReceptor expressionSensory neuronsTrophic supportGABAA receptor agonist muscimolDorsal root ganglion neuronsAxotomized sensory neuronsReactive Schwann cellsGABAA receptor expressionAdult sensory neuronsReceptor agonist muscimolExpression of receptorsPeripheral target tissuesGABA receptor expressionDorsal root fibersGABA receptor sensitivityEnd organ innervationPostoperative dayNerve crushNerve transectionCrush siteDistal stump
1988
Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury
Kingery W, Fields R, Kocsis J. Diminished dorsal root GABA sensitivity following chronic peripheral nerve injury. Experimental Neurology 1988, 100: 478-490. PMID: 3366201, DOI: 10.1016/0014-4886(88)90033-7.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidPrimary afferent depolarizationDorsal rootsGABA sensitivityNerve lesionsSciatic nerveDorsal root compound action potentialsChronic peripheral nerve injurySciatic crush injurySciatic nerve lesionChronic pain syndromeLumbar dorsal rootsPeripheral nerve injuryPeripheral nerve lesionsPeripheral nerve transectionSucrose gap chamberCompound action potentialDorsal root fibersRat lumbar dorsal rootsDorsal root axotomyPain syndromeNerve injuryCrush injuryNerve transectionSciatic axotomy
1987
Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve
Bhisitkul R, Villa J, Kocsis J. Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve. Experimental Brain Research 1987, 66: 659-663. PMID: 3038587, DOI: 10.1007/bf00270698.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidVentral root fibersGABA receptorsRoot fibersSensory fibersPeripheral nervesSensory axonsRegenerated sensory axonsSucrose gap chamberPeripheral nerve fibersRat peripheral nerveDorsal root fibersMammalian peripheral nervesAgonist baclofenNerve crushDorsal rootsAgonist muscimolSciatic nerveNerve fibersRat peripheral nerve fibersNerveReceptorsMuscimolSelective presenceAxons
1984
Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex.
Kocsis J, Eng D, Bhisitkul R. Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6531-6534. PMID: 6093104, PMCID: PMC391958, DOI: 10.1073/pnas.81.20.6531.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSynaptic activityCerebellar cortexAction of adenosineEfficacy of adenosineRat cerebellar cortexClimbing fiber inputParallel fibersAdenosine applicationSynaptic potentialsSynaptic transmissionFiber activityPurkinje cellsAxon excitabilityElectrophysiological techniquesExcitability propertiesDendritic membraneCortexAdenosineConvergent parallelSelective blockingDirect alterationExcitability