2021
Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.
Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 402-411. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionInduction of MCAOCorpus callosumMesenchymal stem cellsChronic phaseMotor functionRat modelWeek 8Vehicle groupInterhemispheric connectionsAdministration of MSCsChronic cerebral ischemia modelNeural connectionsChronic stroke modelCerebral artery occlusionChronic cerebral ischemiaIschemic lesion volumeLong-term disabilityGreater functional improvementCerebral ischemia modelEnhanced functional recoveryAnti-neurofilament antibodiesDiffusion tensorSingle systemic infusionStem cells
2005
I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat
Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis J. I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 2005, 136: 161-169. PMID: 16229956, PMCID: PMC2605391, DOI: 10.1016/j.neuroscience.2005.06.062.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorMesenchymal stem cell groupBrain-derived neurotrophic factor contributesMiddle cerebral artery occlusionStem cell groupCerebral artery occlusionCerebral ischemia modelMesenchymal stem cellsNeurotrophic factorArtery occlusionCell groupsIschemia modelPermanent middle cerebral artery occlusionRat cerebral ischemia modelHuman mesenchymal stem cellsBrain-derived neurotrophic factor (BDNF) geneStem cellsControl sham groupTreadmill stress testRats 6 hFactor contributesNeurotrophic factor geneIntraluminal vascular occlusionAdult bone marrowCerebral ischemiaIntravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat
Honma T, Honmou O, Iihoshi S, Harada K, Houkin K, Hamada H, Kocsis J. Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Experimental Neurology 2005, 199: 56-66. PMID: 15967439, PMCID: PMC2605388, DOI: 10.1016/j.expneurol.2005.05.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDBehavior, AnimalBrain IschemiaCell CountCells, CulturedDisease Models, AnimalExercise TestGreen Fluorescent ProteinsHumansImmunohistochemistryInfusions, IntravenousMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsPhosphopyruvate HydrataseRatsRats, Sprague-DawleyTime FactorsConceptsMiddle cerebral artery occlusionIntravenous infusionFunctional outcomeLesion sizeTransient middle cerebral artery occlusionMesenchymal stem cellsCerebral artery occlusionCerebral infarction volumeCerebral ischemia modelSpinal cord injurySubsequent histological examinationPotential therapeutic benefitRats 12 hMorris water mazeBone marrow cellsHuman mesenchymal stem cellsStem cellsHTERT-MSCsArtery occlusionInfarction volumeCerebral ischemiaCord injuryFunctional improvementLesion volumeIschemia model28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons
Kocsis J, Sasaki M. 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons. 2005, 421-433. DOI: 10.1016/b978-012738761-1/50029-8.Peer-Reviewed Original ResearchTransplantation of SCsTransplantation of OECsSpinal cord injuryCentral nervous systemSchwann cellsAxonal regenerationBone marrow cellsFunctional recoveryMultiple sclerosisCell transplantationCord injurySpinal cordHind limb locomotor functionContusive spinal cord injuryBone marrow cell transplantationMarrow cellsSpinal cord injury modelMarrow cell transplantationCerebral ischemia modelSpinal cord resultsGlobal neuroprotectionDemyelination modelCord resultsFunctional outcomeDemyelinated axons