2020
Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice
Escamilla-Rivera V, Liu J, Gibb DR, Santhanakrishnan M, Liu D, Forsmo JE, Eisenbarth S, Foxman EF, Stowell SR, Luckey CJ, Zimring JC, Hudson KE, Hendrickson J. Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. Blood 2020, 135: 1983-1993. PMID: 32266378, PMCID: PMC7256361, DOI: 10.1182/blood.2020005018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCytokinesDisease Models, AnimalErythroblastosis, FetalErythrocyte TransfusionErythrocytesFemaleHumansImmunization, PassiveInterferon Type IIsoantigensKell Blood-Group SystemMembrane GlycoproteinsMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhagocytosisPoly I-CPregnancyConceptsRed blood cellsSerum monocyte chemoattractant protein-1Monocyte chemoattractant protein-1Blood cellsHuman KEL glycoproteinPolyinosinic-polycytidilic acidTransfused red blood cellsType 1 IFNType I IFN receptorChemoattractant protein-1Type 1 interferonI IFN receptorMurine red blood cellsRecipient CD4Recipient inflammationIFN administrationSerum cytokinesInflammatory monocytesRecipient treatmentInterleukin-6Hemolytic diseaseT cellsMurine modelAlloimmunizationKnockout mice
2018
3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice
Madrid D, Gibb D, Natarajan P, Santhanakrishnan M, Liu J, Hendrickson J. 3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice. American Journal Of Clinical Pathology 2018, 149: s164-s164. DOI: 10.1093/ajcp/aqx149.372.Peer-Reviewed Original ResearchCD40/CD40 ligand interactionsCD40 ligand interactionsCD40/CD40L blockadeWild-type animalsRed blood cellsNonresponder animalsCD40L blockadeWeeks posttransfusionType animalsIgG antibodiesT cellsImmune responseMonoclonal antibodiesAbsence of CD4CD40 ligand blockadeHuman KEL glycoproteinFlow cytometric crossmatchHemolytic transfusion reactionsDurable immune responsesHumoral immune responseWild-type miceDevelopment of alloantibodiesT cell interactionsMurine red blood cellsAlloantibody responses
2017
Interleukin-6 receptor α signaling on CD4+ T cells drives RBC alloantibody generation and T follicular helper cell differentiation in a murine model of RBC alloimmunization.
Arneja A, Salazar J, Jiang W, Hendrickson J, Zimring J, Luckey C. Interleukin-6 receptor α signaling on CD4+ T cells drives RBC alloantibody generation and T follicular helper cell differentiation in a murine model of RBC alloimmunization. The Journal Of Immunology 2017, 198: 201.27-201.27. DOI: 10.4049/jimmunol.198.supp.201.27.Peer-Reviewed Original ResearchRBC alloimmunizationRed blood cellsIL-6RαT cellsAntigen-negative red blood cellsFollicular helper cell differentiationInterleukin-6 receptor αFollicular helper cellsHemolytic transfusion reactionsViable therapeutic optionLife-saving therapySignificant clinical problemSignificant clinical consequencesInterleukin-6 receptorHelper cell differentiationSpecific CD4Multiple alloantibodiesOccasional mortalitySignificant morbidityTherapeutic optionsAvailable biologicsFunctional outcomeHelper cellsTransfusion reactionsClinical consequences
2015
DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2015, 126: 658. DOI: 10.1182/blood.v126.23.658.658.Peer-Reviewed Original ResearchAllogeneic red blood cellsDOCK8-deficient miceRed blood cellsT cellsDendritic cellsT cell activationAllogeneic responseB cellsImmune signalsCell activationT cell receptor transgenic miceSplenic dendritic cell subsetsBlood cellsDendritic cell activityInduction of alloimmunityDendritic cell subsetsHen egg lysozymeT cell primingDendritic cell migrationInnate immune cellsReceptor transgenic miceInnate immune signalsT cell zonesAntigen presenting cellsB cell responses
2014
CD8+ T Cells Mediate Antibody-Independent Platelet Clearance Following Transfusion
Patel S, Arthur C, Rodrigues L, Xue C, Zimring J, Hendrickson J, Stowell S. CD8+ T Cells Mediate Antibody-Independent Platelet Clearance Following Transfusion. Blood 2014, 124: 596. DOI: 10.1182/blood.v124.21.596.596.Peer-Reviewed Original ResearchPlatelet-rich plasmaMajor histocompatibility complexNK cell depletionT cellsPlatelet clearanceC57BL/6 recipientsPlatelet transfusionsNK cellsCellular immunityCell depletionAnti-MHC antibodiesSubsequent blood transfusionDepletion of CD8Solid organ allograftsAnti-platelet antibodiesCD8 T cellsClearance of plateletsPlatelet transfusion therapyFlow cytometric analysisLater time pointsC57BL/6 donorsMHC alloantibodiesNK1.1 antibodyOrgan allograftsBlood transfusionNLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. NLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2014, 124: 4113. DOI: 10.1182/blood.v124.21.4113.4113.Peer-Reviewed Original ResearchAllogeneic red blood cellsRed blood cellsDendritic cellsT cell activationT cellsBlood cellsIntegral membrane proteinsAllogeneic responseBeta-globin promoterB cellsImmune signalsTriple fusion proteinCell activationT cell receptor transgenic miceInnate immune cytokine responsesRounds of divisionDendritic cell activityInduction of alloimmunityHen egg lysozymeSplenic dendritic cellsT cell primingReceptor transgenic miceImmune cytokine responsesInnate immune signalsGlobin promoter
2013
KEL RBC Transfusion Induces IgG Anti-KEL Antibodies Independent Of CD4 T Cells
Stowell S, Girard-Pierce K, Arthur C, Smith N, Zimring J, Hendrickson J. KEL RBC Transfusion Induces IgG Anti-KEL Antibodies Independent Of CD4 T Cells. Blood 2013, 122: 41. DOI: 10.1182/blood.v122.21.41.41.Peer-Reviewed Original ResearchCD4 T cellsMHC class IIRBC alloantibody formationRBC transfusionT cellsKEL RBCsIsotype controlAlloantibody formationC57BL/6 recipientsRBC alloantibodiesRBC alloantigensClass IICD-4 T-cellsCD4 T-cell depletionRed blood cell transfusionCD4 T cell helpMHC class II antigensChronic transfusion therapyBlood cell transfusionT-cell depletionHemolytic transfusion reactionsIsotype control antibodyClass II antigensT cell helpMHC antigen presentationAlterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease
Nickel R, Hendrickson J, Horan J, Garrett A, Robertson J, Osunkwo I, Kean L. Alterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease. Blood 2013, 122: 2208. DOI: 10.1182/blood.v122.21.2208.2208.Peer-Reviewed Original ResearchSickle cell diseaseWhite blood cellsTotal white blood cellsChronic transfusionImmune cell subsetsHU patientsImmune cell populationsSCD patientsT cellsCell subsetsHealthy controlsCell diseaseB cellsGraft rejectionNK cellsImmune systemBone marrow transplant rejectionT-cell subset analysisCell populationsRed blood cell alloimmunizationPediatric sickle cell diseaseSpecific immune cell subsetsDifferent immune cell populationsAbnormal immune activationB cell analysis
2012
Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway
Stowell S, Liepkalns J, Hendrickson J, Pierce K, Smith N, Zimring J. Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway. Blood 2012, 120: 3290. DOI: 10.1182/blood.v120.21.3290.3290.Peer-Reviewed Original ResearchHOD RBCsKO miceSurface C3Nonimmunized miceAntigen levelsT cellsAntibody-reactive antigensC3 KO miceComplement inhibitory factorsAutoimmune hemolytic anemiaCell-mediated destructionAntibody-mediated destructionComplement-dependent mechanismAntibody-mediated processComplement-independent pathwaysComplement-independent mechanismsAntibody-secreting cellsNonimmunized control miceComplement degradation productsAntibody engagementCellular protectionCellular resistanceHOD antigenSubsequent transfusionsAntibody levels
2011
Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis
Hudson K, Hendrickson J, Cadwell C, Iwakoshi N, Zimring J. Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis. Blood 2011, 118: 693. DOI: 10.1182/blood.v118.21.693.693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaT cell toleranceOVA/CFAB cell tolerancePathogenesis of AIHAReactive T cellsT cellsHOD antigenAdoptive transferPeripheral toleranceCell toleranceB cellsB6 miceHen egg lysozymeHOD RBCsReactive CD4Humoral toleranceF1 miceImmune responseAntigen expressionTransgenic miceWild-type B6 miceWild-type C57BL/6 micePeripheral B cell toleranceOT-II CD4
2007
An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells. Blood 2007, 110: 453. DOI: 10.1182/blood.v110.11.453.453.Peer-Reviewed Original ResearchNon-splenectomized miceRBC alloimmunizationT cellsSplenectomized miceDivision of CD4Adoptive transferRed blood cellsPrecursor frequencyHelper T-cell precursor frequencyT cell precursor frequencyHelper T cell functionHelper T cell responsesBlood cellsHuman dose equivalentRate of alloimmunizationAntigen-specific CD4T cell responsesIgG-specific ELISACell precursor frequencyT cell functionDetectable alloantibodiesPatient populationIntact spleenLymphatic preparationsMurine model
2006
Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells. Blood 2006, 108: 23. DOI: 10.1182/blood.v108.11.23.23.Peer-Reviewed Original ResearchLiver dendritic cellsDendritic cellsT cellsRBC antigensRed blood cellsImmune responseSplenic macrophagesB cellsRBC consumptionCo-stimulatory molecule expressionBlood cellsRed blood cell antigensMajority of patientsC57BL/6 recipient micePresence of inflammationAbsence of inflammationRole of antigenLymph node macrophagesBlood cell antigensRBC alloimmunizationRecipient inflammationAlloantibody responsesLymph nodesRBC transfusionPotent APCs