A Genetic Basis for Donor Variation in Generation of Prostaglandins and Leukotrienes in Stored RBCs Using a Mouse Model
Zimring J, Smith N, Stowell S, Francis R, Hod E, Hendrickson J, Dumont L, Roback J, Spitalnik S. A Genetic Basis for Donor Variation in Generation of Prostaglandins and Leukotrienes in Stored RBCs Using a Mouse Model. Blood 2012, 120: 844. DOI: 10.1182/blood.v120.21.844.844.Peer-Reviewed Original ResearchMouse modelRBC unitsArachidonic acidProstaglandin E2Eicosanoid generationRBC storageNegative clinical sequelaeSubstantial time-dependent increaseType of anemiaDonor variationGeneration of prostaglandinsOxidative damageTime-dependent increaseClinical sequelaeRBC transfusionEicosanoid levelsAdverse outcomesClear efficacyDonor miceFVB miceVascular pathologyPotent mediatorDay 0Alpha-tocopherolProduction of lactate