2022
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice
Arthur CM, Patel SR, Sharma A, Zerra PE, Chonat S, Jajosky RP, Fasano RM, Patel R, Bennett A, Zhou X, Luckey CJ, Hudson KE, Eisenbarth SC, Josephson CD, Roback JD, Hendrickson JE, Stowell SR. Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice. Transfusion 2022, 62: 948-953. PMID: 35470900, PMCID: PMC9491148, DOI: 10.1111/trf.16872.Peer-Reviewed Original ResearchConceptsRBC alloimmunizationRBC transfusionAntibody formationPreclinical modelsRed blood cell transfusionBlood cell alloantigensBlood cell transfusionTransfusion of RBCsTransfusion-dependent patientsDevelopment of alloantibodiesIgG antibody formationAlloantigen exposureHOD RBCsCell transfusionPost transfusionAlloantibody formationPharmacological removalIgG antibodiesTransfusionAlloimmunizationClodronateMarginal sinusPrior treatmentDay 5KEL antigen
2015
Antigen Density Impacts RBC Survival and Antigen Modulation Following Incompatible RBC Transfusion
Yoo J, Arthur C, Zerra P, Girard-Pierce K, Hendrickson J, Stowell S. Antigen Density Impacts RBC Survival and Antigen Modulation Following Incompatible RBC Transfusion. Blood 2015, 126: 2350. DOI: 10.1182/blood.v126.23.2350.2350.Peer-Reviewed Original ResearchIncompatible RBC transfusionHemolytic transfusion reactionsWild-type C57BL/6 miceRBC transfusionIncompatible transfusionsAntigen densityAntigen modulationFlow cytometric analysisKEL antigenRBC survivalKEL RBCsImmunized recipientsAntigen levelsCytometric analysisFatal hemolytic transfusion reactionRecipient WT miceChronic transfusion therapyTransfusion of RBCsNon-immunized miceLow antigen densityAntibody-mediated removalAlloimmunized individualsAdverse eventsDonor antigensPost transfusion
2013
Transfusion Of RBCs With Low-Density KEL Induces Tolerance To The KEL Antigen
Stowell S, Arthur C, Smith N, Girard-Pierce K, Zimring J, Hendrickson J. Transfusion Of RBCs With Low-Density KEL Induces Tolerance To The KEL Antigen. Blood 2013, 122: 1160. DOI: 10.1182/blood.v122.21.1160.1160.Peer-Reviewed Original ResearchKEL RBCsRBC transfusionAntibody formationKEL antigenDetectable IgMRBC alloimmunizationWestern blot analysisC57BL/6 recipientsAntigen densityDay 3RBC antigensDays post transfusionTransfusion of RBCsSubsequent responseBlot analysisFlow cytometric analysisAnalysis of serumCompatible RBCsRBC alloantigensRepeat transfusionPost transfusionAntigen levelsImmunological outcomesRBC exposureSpecific alloantibodies