2022
Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88.
Soldatenko A, Hoyt LR, Xu L, Calabro S, Lewis SM, Gallman AE, Hudson KE, Stowell SR, Luckey CJ, Zimring JC, Liu D, Santhanakrishnan M, Hendrickson JE, Eisenbarth SC. Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. The Journal Of Immunology 2022, 208: 991-997. PMID: 35039331, PMCID: PMC10107373, DOI: 10.4049/jimmunol.2100784.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsDendritic cellsDC activationAdaptive immunityClass of PRRsNon-ABO alloantibodiesRecipient dendritic cellsSplenic dendritic cellsMouse RBCsInflammatory cytokine responseTreatment of anemiaRBC transfusion therapyTransfused RBCsAlloantibody responsesAllogeneic RBCsSerious complicationsCytokine responsesTransfusion therapyRecognition receptorsMyD88TransfusionAlloimmunizationRBCsTRIFUnknown mechanism
2017
Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies
Hendrickson J. Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies. ISBT Science Series 2017, 13: 105-111. DOI: 10.1111/voxs.12360.Peer-Reviewed Original ResearchAnimal modelsChronic inflammatory disease statesRBC unitsAntigen-specific toleranceT-cell markersInduction of immunityInflammatory disease statesHumoral immune responseHumoral immune responsivenessAlloantibody developmentRBC alloimmunisationDonor antigensDendritic cellsRBC alloantibodiesRBC transfusionTransfusion recipientsImmune responsivenessRBC exposureRisk factorsMurine studiesForeign antigensImmune responseCD 4Danger signalsImmune system
2016
Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice
Gibb D, Natarajan P, Liu J, Santhanakrishnan M, Iwasaki A, Hendrickson J. Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice. Blood 2016, 128: 19. DOI: 10.1182/blood.v128.22.19.19.Peer-Reviewed Original ResearchMonocyte-derived dendritic cellsReactivity of seraPeak antibody responseWT miceIfnar1-/- miceType 1 interferonDendritic cellsRBC transfusionPeripheral bloodAntibody responseRBC alloimmunizationAlloimmune responseSpecific IgGIgG antibodiesInflammatory diseasesMouse modelRBC antigensIndividual miceCCR2-/- miceFrequency of alloimmunizationHuman KEL glycoproteinFlow cytometric crossmatchActivation marker expressionDendritic cell activationRole of inflammation
2015
DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2015, 126: 658. DOI: 10.1182/blood.v126.23.658.658.Peer-Reviewed Original ResearchAllogeneic red blood cellsDOCK8-deficient miceRed blood cellsT cellsDendritic cellsT cell activationAllogeneic responseB cellsImmune signalsCell activationT cell receptor transgenic miceSplenic dendritic cell subsetsBlood cellsDendritic cell activityInduction of alloimmunityDendritic cell subsetsHen egg lysozymeT cell primingDendritic cell migrationInnate immune cellsReceptor transgenic miceInnate immune signalsT cell zonesAntigen presenting cellsB cell responses
2014
NLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. NLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2014, 124: 4113. DOI: 10.1182/blood.v124.21.4113.4113.Peer-Reviewed Original ResearchAllogeneic red blood cellsRed blood cellsDendritic cellsT cell activationT cellsBlood cellsIntegral membrane proteinsAllogeneic responseBeta-globin promoterB cellsImmune signalsTriple fusion proteinCell activationT cell receptor transgenic miceInnate immune cytokine responsesRounds of divisionDendritic cell activityInduction of alloimmunityHen egg lysozymeSplenic dendritic cellsT cell primingReceptor transgenic miceImmune cytokine responsesInnate immune signalsGlobin promoter
2008
Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice
HendricKson J, Archer D, Perry J, Hillyer C, Zimring J. Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice. Blood 2008, 112: 292. DOI: 10.1182/blood.v112.11.292.292.Peer-Reviewed Original ResearchCo-stimulatory molecule expressionSickle cell diseaseBerkeley miceAntigen presenting cellsCell diseaseSickle cell traitMolecule expressionForeign antigensRBC alloimmunizationBaseline inflammationDendritic cellsPresenting cellsRed blood cell alloimmunizationCell traitIndividual miceELISA 2 weeksRate of alloimmunizationRBC-specific expressionTransfusion of RBCsHuman blood group antigensLevel of illnessAntigen hen egg lysozymeDonor/recipientHigh rateTime of illness
2006
Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells. Blood 2006, 108: 23. DOI: 10.1182/blood.v108.11.23.23.Peer-Reviewed Original ResearchLiver dendritic cellsDendritic cellsT cellsRBC antigensRed blood cellsImmune responseSplenic macrophagesB cellsRBC consumptionCo-stimulatory molecule expressionBlood cellsRed blood cell antigensMajority of patientsC57BL/6 recipient micePresence of inflammationAbsence of inflammationRole of antigenLymph node macrophagesBlood cell antigensRBC alloimmunizationRecipient inflammationAlloantibody responsesLymph nodesRBC transfusionPotent APCs