2023
Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice
Maier C, Jajosky R, Patel S, Verkerke H, Fuller M, Allen J, Zerra P, Fasano R, Chonat S, Josephson C, Gibb D, Eisenbarth S, Luckey C, Hudson K, Hendrickson J, Arthur C, Stowell S. Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice. Transfusion 2023, 63: 457-462. PMID: 36708051, PMCID: PMC10414794, DOI: 10.1111/trf.17251.Peer-Reviewed Original ResearchConceptsKEL RBCsAntibody formationAntigen levelsRed blood cell alloimmunizationIgG antibody productionDifferent clinical outcomesIgG antibody formationRed cell antigensAlloantibody productionRBC alloimmunizationClinical outcomesTransfusionAlloimmunizationRBC clearanceCell antigensClinical experienceSpecific antigenAntibody productionRBC antigensRBC survivalAntibody developmentModel antigenAntigenAdditional studiesFresh RBCs
2022
FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization
Qiu A, Miller A, Dei Zotti F, Santhanakrishnan M, Hendrickson JE, Tredicine M, Stowell SR, Luckey CJ, Zimring JC, Hudson KE. FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization. Frontiers In Immunology 2022, 13: 972723. PMID: 36189253, PMCID: PMC9519184, DOI: 10.3389/fimmu.2022.972723.Peer-Reviewed Original ResearchConceptsAlloantibody productionRBC alloimmunizationPassive immunizationRBC clearanceSplenic dendritic cell subsetsRed blood cell transfusionSplenic conventional DCsBlood cell transfusionDendritic cell subsetsConventional DCsFc gamma receptorsHumoral alloimmunizationAlloantibody responsesCell transfusionMaternal alloimmunizationCell subsetsFcγR expressionIgG antibodiesHemolytic diseaseBlocking antibodiesAlloimmunizationImmune complexesMouse modelKnockout miceAntibodies