2011
Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis
Hudson K, Hendrickson J, Cadwell C, Iwakoshi N, Zimring J. Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis. Blood 2011, 118: 693. DOI: 10.1182/blood.v118.21.693.693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaT cell toleranceOVA/CFAB cell tolerancePathogenesis of AIHAReactive T cellsT cellsHOD antigenAdoptive transferPeripheral toleranceCell toleranceB cellsB6 miceHen egg lysozymeHOD RBCsReactive CD4Humoral toleranceF1 miceImmune responseAntigen expressionTransgenic miceWild-type B6 miceWild-type C57BL/6 micePeripheral B cell toleranceOT-II CD4
2007
An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells. Blood 2007, 110: 453. DOI: 10.1182/blood.v110.11.453.453.Peer-Reviewed Original ResearchNon-splenectomized miceRBC alloimmunizationT cellsSplenectomized miceDivision of CD4Adoptive transferRed blood cellsPrecursor frequencyHelper T-cell precursor frequencyT cell precursor frequencyHelper T cell functionHelper T cell responsesBlood cellsHuman dose equivalentRate of alloimmunizationAntigen-specific CD4T cell responsesIgG-specific ELISACell precursor frequencyT cell functionDetectable alloantibodiesPatient populationIntact spleenLymphatic preparationsMurine model