2009
PI3K/Akt signalling‐mediated protein surface expression sensed by 14‐3‐3 interacting motif
Chung J, Okamoto Y, Coblitz B, Li M, Qiu Y, Shikano S. PI3K/Akt signalling‐mediated protein surface expression sensed by 14‐3‐3 interacting motif. The FEBS Journal 2009, 276: 5547-5558. PMID: 19691494, PMCID: PMC4301307, DOI: 10.1111/j.1742-4658.2009.07241.x.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAmino Acid MotifsAmino Acid SequenceAnimalsBinding SitesCattleCell LineCell MembraneHumansMembrane ProteinsPhosphatidylinositol 3-KinasesPhosphorylationProtein BindingProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledReceptors, PeptideRecombinant Fusion ProteinsSignal TransductionTransfectionConceptsCell surface expressionMembrane proteinsEndoplasmic reticulum localization signalsSurface expressionDifferent extracellular signalsFetal bovine serumPost-translational modificationsSpecific protein localizationG protein-coupled receptorsDominant-negative AktC-terminal sequencesKinase B pathwayProtein-coupled receptorsGenetic screenCell surface membraneLocalization signalCargo proteinsActive kinaseExtracellular signalingExtracellular signalsProtein localizationProtein surface expressionKinase activityBovine serumCellular responses
2003
Genome-wide Analyses of Carboxyl-terminal Sequences*
Chung JJ, Yang H, Li M. Genome-wide Analyses of Carboxyl-terminal Sequences*. Molecular & Cellular Proteomics 2003, 2: 173-181. PMID: 12682279, DOI: 10.1074/mcp.m300008-mcp200.Peer-Reviewed Original ResearchConceptsCarboxyl-terminal sequenceBiological functionsYeast open reading framesTerminal sequenceGenome-wide analysisProtein carboxyl terminusCarboxyl-terminal signalUnknown biological functionEndoplasmic reticulum retentionSpecific biological functionsOpen reading frameHDEL sequenceProteome levelSequence motifsEntire proteomeProteome databaseReading frameCarboxyl terminusRecognition signatureBiochemical processesFunctional classificationProteomeSequenceDetermination of proteinProtein
2002
Functional diversity of protein C-termini: more than zipcoding?
Chung J, Shikano S, Hanyu Y, Li M. Functional diversity of protein C-termini: more than zipcoding? Trends In Cell Biology 2002, 12: 146-150. PMID: 11859027, DOI: 10.1016/s0962-8924(01)02241-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProtein C-terminusC-terminusProtein domainsTermini of proteinsCell biological processesTerminal sequence motifCell biological functionsProtein targetingTPR domainFunctional proteomicsFunctional diversitySequence motifsAlpha-carboxyl groupPosttranslational modificationsSequence diversityMacromolecular complexesProtein degradationDiverse functionsTerminal alpha-carboxyl groupBiological processesRecognition signatureTemporal specificityDiversityTerminal epitopesCombination of diversity