2009
PI3K/Akt signalling‐mediated protein surface expression sensed by 14‐3‐3 interacting motif
Chung J, Okamoto Y, Coblitz B, Li M, Qiu Y, Shikano S. PI3K/Akt signalling‐mediated protein surface expression sensed by 14‐3‐3 interacting motif. The FEBS Journal 2009, 276: 5547-5558. PMID: 19691494, PMCID: PMC4301307, DOI: 10.1111/j.1742-4658.2009.07241.x.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAmino Acid MotifsAmino Acid SequenceAnimalsBinding SitesCattleCell LineCell MembraneHumansMembrane ProteinsPhosphatidylinositol 3-KinasesPhosphorylationProtein BindingProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledReceptors, PeptideRecombinant Fusion ProteinsSignal TransductionTransfectionConceptsCell surface expressionMembrane proteinsEndoplasmic reticulum localization signalsSurface expressionDifferent extracellular signalsFetal bovine serumPost-translational modificationsSpecific protein localizationG protein-coupled receptorsDominant-negative AktC-terminal sequencesKinase B pathwayProtein-coupled receptorsGenetic screenCell surface membraneLocalization signalCargo proteinsActive kinaseExtracellular signalingExtracellular signalsProtein localizationProtein surface expressionKinase activityBovine serumCellular responses
2001
9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element
Cho S, Chung J, Han J, Lee B, Do Han Kim, Rhee K, Kim K. 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element. Brain Research 2001, 87: 214-222. PMID: 11245924, DOI: 10.1016/s0169-328x(01)00020-1.Peer-Reviewed Original ResearchMeSH KeywordsAlitretinoinAnimalsAntineoplastic AgentsCells, CulturedDose-Response Relationship, DrugGene Expression RegulationGonadotropin-Releasing HormoneLigandsPromoter Regions, GeneticRatsReceptors, Retinoic AcidRetinoid X ReceptorsRNA, MessengerTranscription FactorsTranscription, GeneticTransfectionTretinoinConceptsGT1-1 cellsRat GnRH promoterPromoter-driven luciferase activityRetinoid X receptorTrans-RAGnRH expressionGnRH transcriptionLuciferase activityImmortalized GnRH neuronsRXR beta expressionGnRH promoterVehicle-treated controlsGnRH mRNA levelsGonadotropin-releasing hormone gene transcriptionGnRH gene expressionGonadotropin-releasing hormone (GnRH) geneTime-related mannerGnRH promoter activityTrans retinoic acidGnRH gene transcriptionTime-dependent mannerGnRH neuronsPresent studyBeta expressionResponse element