2004
Estimating the relative risk of developing melanoma in INK4A carriers
Berwick M, Orlow I, Mahabir S, Myskowski P, Coit D, Brady M, Roy P, Song Y, Canchola R, Barz A, Halpern A, Bolognia J, Eng S, Elahi A, Begg C. Estimating the relative risk of developing melanoma in INK4A carriers. European Journal Of Cancer Prevention 2004, 13: 65-70. PMID: 15075790, DOI: 10.1097/00008469-200402000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCase-Control StudiesChromatography, LiquidCyclin-Dependent Kinase Inhibitor p16FemaleGerm-Line MutationHumansMaleMelanomaMiddle AgedNeoplasms, Multiple PrimaryNevusNucleic Acid DenaturationOdds RatioPilot ProjectsPolymerase Chain ReactionPrevalenceRisk FactorsSkin NeoplasmsSurveys and QuestionnairesConceptsRisk factorsRelative riskMemorial Sloan-Kettering Cancer CenterStudy designSingle primaryCancer risk factorsMultiple primary melanomasRisk of melanomaNumber of neviPigmented lesion clinicNovel study designRare germline mutationsDermatology clinicCancer CenterNew study designsPrimary melanomaLesion clinicHigh prevalencePrimary casesPatientsMultiple primariesMelanomaGermline mutationsPilot studyFair skin
2001
The Melanocortin-1 Receptor: Red Hair and Beyond
Schaffer J, Bolognia J. The Melanocortin-1 Receptor: Red Hair and Beyond. JAMA Dermatology 2001, 137: 1477-1485. PMID: 11708951, DOI: 10.1001/archderm.137.11.1477.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMelanocortin 1 receptorTransmembrane-spanning domainsG protein-coupled receptorsProtein-coupled receptorsRed hair phenotypeHuman pigmentationPigmentation phenotypesHair phenotypePheomelanin synthesisRed hairType of melaninHeterozygote effectUV-induced melanogenesisNonmelanoma skin cancerPhenotypeDecreased abilityReceptorsKey roleMelanocortin receptorsSkin cancerLociGeneticsFair skinPhysiologic variationsVariants