2021
Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin
Wang G, Kitaoka T, Crawford A, Mao Q, Hesketh A, Guppy FM, Ash GI, Liu J, Gerstein MB, Pitsiladis YP. Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin. Scientific Reports 2021, 11: 21705. PMID: 34737331, PMCID: PMC8568984, DOI: 10.1038/s41598-021-00608-9.Peer-Reviewed Original ResearchConceptsRNA-seqDifferential gene expressionPathway enrichment analysisRNA biologyTranscriptomic profilingTarget genesEnrichment analysisGene expressionEPO biologyMicroarray platformGene correlateCross-platform comparisonGenesBiologyImmune regulationHuman erythropoietinTissue protectionProfilingRegulationErythropoietinRecombinant human erythropoietinExpressionImportant toolErythropoiesisOxygen transport
2020
RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins
Zhang J, Liu J, Lee D, Feng JJ, Lochovsky L, Lou S, Rutenberg-Schoenberg M, Gerstein M. RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins. Genome Biology 2020, 21: 151. PMID: 32727537, PMCID: PMC7391703, DOI: 10.1186/s13059-020-01979-4.Peer-Reviewed Original ResearchConceptsTissue-specific inputsPost-transcriptional regulationDisease-specific variantsPrioritization of variantsVariant prioritization methodsTranscriptional regulationRNA structureBinding sitesRNAProteinPrioritization methodRegulationKey roleVariantsRegulomeGenomeSplicingGermlineExonsOverall impact scoreMotifConservationAnnotationDysregulation