Association of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adultsBiomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseChronic kidney diseaseEGFR declineCardiac surgeryHeart diseaseUrine uromodulinMedian eGFRIL-18Study visitGraphical abstractA higher resolution versionLong-term chronic kidney diseaseGlomerular filtration rate declineFaster eGFR declineIL-18 concentrationsLower median eGFRSurgical complexity scoreAcyanotic heart diseaseCongenital heart diseaseSubgroup of childrenTubular healthOverall cohortClinical factorsUrine biomarkersKidney diseaseUrinary biomarkers