2023
Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseChronic kidney diseaseEGFR declineCardiac surgeryHeart diseaseUrine uromodulinMedian eGFRIL-18Study visitGraphical abstractA higher resolution versionLong-term chronic kidney diseaseGlomerular filtration rate declineFaster eGFR declineIL-18 concentrationsLower median eGFRSurgical complexity scoreAcyanotic heart diseaseCongenital heart diseaseSubgroup of childrenTubular healthOverall cohortClinical factorsUrine biomarkersKidney diseaseUrinary biomarkers
2021
Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study
Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdolescentCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansHypertensionIncidenceInfantInfant, NewbornKidney Failure, ChronicMaleMortalityOntarioProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSurvivorsTime FactorsConceptsAKI survivorsKidney failureLong-term riskCohort studyCox proportional hazards regression analysisAdverse short-term outcomesChildhood acute kidney injuryProportional hazards regression analysisHigher long-term riskAcute kidney injuryHealth administrative databasesRetrospective cohort studyHazards regression analysisShort-term outcomesLong-term outcomesBasis of ageAKI episodesPediatric AKISubsequent AKIKidney injuryComposite outcomeCardiac surgeryHospitalized cohortMechanical ventilationPediatric hospitalizations