Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall
Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C. Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall. Bioconjugate Chemistry 2019, 31: 360-368. PMID: 31095372, PMCID: PMC7460274, DOI: 10.1021/acs.bioconjchem.9b00256.Peer-Reviewed Original ResearchConceptsAtherosclerotic vessel wallPositron emission tomographyVascular permeabilityVessel wallEmission tomographyRabbit atherosclerosis modelExperimental treatment optionsPET/magnetic resonance imagingDynamic contrast-enhanced MRIMultimodal positron emission tomographyContrast-enhanced MRIMagnetic resonance imagingDevelopment of nanotherapyNoninvasive imaging approachPET/MRIAtherosclerotic diseaseAtherosclerosis modelTreatment optionsAbdominal aortaIntravenous injectionAtherosclerotic lesionsResonance imagingPET/Treatment evaluationBiodistribution pattern