2024
High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas
Sandooja R, Saini J, Kittithaworn A, Gregg-Garcia R, Dogra P, Atkinson E, Yu K, Fell V, Simha V, Connelly M, Dullaart R, Bancos I. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae392. PMID: 38870260, DOI: 10.1210/clinem/dgae392.Peer-Reviewed Original ResearchTriglyceride-rich lipoprotein particlesNonfunctioning adenomasCushing's syndromePatient categoriesLow density lipoprotein particlesSex-adjusted analysesHigh density lipoprotein particlesApoB concentrationsLipid lowering drug therapyCross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAdrenal cortical adenomaAutonomous cortisol secretionLipid lowering therapyLipoprotein particlesMultivariate logistic analysisIncreased cardiovascular riskLow density lipoprotein particle concentrationAge- and sex-adjusted analysesStudy of patientsCross sectional studyCortical adenomaCortisol excessLowering therapyEnhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Kittithaworn A, Dogra P, Saini J, Gruppen E, Atkinson E, Achenbach S, Yu K, Thangamuthu K, Connelly M, Dullaart R, Bancos I. Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae204. PMID: 38546526, DOI: 10.1210/clinem/dgae204.Peer-Reviewed Original ResearchMild autonomous cortisol secretionBranched-chain amino acidsMalignant adrenal massesNonfunctioning adenomasCushing's syndromeAdrenocortical carcinomaAdrenal massPrimary aldosteronismAdrenal disordersIncreasing TMAONon-functioning adrenal massesIncreased branched-chain amino acidsIncreased BCAACross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAutonomous cortisol secretionTrimethylamine N-oxideKetone bodiesAdrenal hormone excessSimilar to patientsMultivariate logistic analysisIncreased cardiovascular riskMetabolite trimethylamine N-oxideStudy of patients
2023
Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study
Rahimi L, Kittithaworn A, Garcia R, Saini J, Dogra P, Atkinson E, Achenbach S, Kattah A, Bancos I. Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e1750-e1758. PMID: 38157409, PMCID: PMC11318994, DOI: 10.1210/clinem/dgad765.Peer-Reviewed Original ResearchMild autonomous cortisol secretionNonfunctioning adrenal adenomasFactors associated with chronic kidney diseaseChronic kidney diseaseTime of diagnosisAdrenal adenomaKidney functionSingle-center retrospective cohort studyMultivariate analysisSingle-center cohort study of patientsSingle-center cohort studyIncreased risk of chronic kidney diseaseCohort study of patientsRisk of chronic kidney diseaseAngiotensin II receptor blockersAutonomous cortisol secretionAngiotensin-converting enzyme inhibitorsTreated with adrenalectomyImpact of adrenalectomyIndependent risk factorRetrospective cohort studyII receptor blockersFollow-up periodStudy of patientsConverting enzyme inhibitorsTHU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Singh S, Fell V, Atkinson E, Achenbach S, Khosla S, Bancos I. THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.135. PMCID: PMC10554199, DOI: 10.1210/jendso/bvad114.135.Peer-Reviewed Original ResearchArea under the curveAutonomous cortisol secretionParathyroid hormoneBone metabolism biomarkersCortisol secretionFree cortisolType 1 collagenBone metabolismReference subjectsCircadian cortisol secretionCarboxy-terminal telopeptide of type 1 collagenMetabolic biomarkersMild autonomous cortisol secretionIncreased risk of fractureCross-sectional study of patientsCortisol productionParathyroid hormone productionDexamethasone suppression testRisk of fractureCarboxy-terminal telopeptideImpaired bone metabolismStudy of patientsCircadian secretory patternClinical research unitIncreased cortisol production