Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study
Kittithaworn A, Dogra P, Saini J, Gruppen E, Atkinson E, Achenbach S, Yu K, Thangamuthu K, Connelly M, Dullaart R, Bancos I. Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae204. PMID: 38546526, DOI: 10.1210/clinem/dgae204.Peer-Reviewed Original ResearchMild autonomous cortisol secretionBranched-chain amino acidsMalignant adrenal massesNonfunctioning adenomasCushing's syndromeAdrenocortical carcinomaAdrenal massPrimary aldosteronismAdrenal disordersIncreasing TMAONon-functioning adrenal massesIncreased branched-chain amino acidsIncreased BCAACross-sectional study of patientsReference subjectsSingle-center cross-sectional studyAutonomous cortisol secretionTrimethylamine N-oxideKetone bodiesAdrenal hormone excessSimilar to patientsMultivariate logistic analysisIncreased cardiovascular riskMetabolite trimethylamine N-oxideStudy of patients