2024
Steroid Profiling and Circadian Cortisol Secretion in Patients with Mild Autonomous Cortisol Secretion: A Cross-Sectional Study
Saini J, Singh S, Ebbehoj A, Zhang C, Nathani R, Fell V, Atkinson E, Achenbach S, Rivard A, Singh R, Grebe S, Bancos I. Steroid Profiling and Circadian Cortisol Secretion in Patients with Mild Autonomous Cortisol Secretion: A Cross-Sectional Study. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae468. PMID: 38981002, DOI: 10.1210/clinem/dgae468.Peer-Reviewed Original ResearchAutonomous cortisol secretionUrine steroid metabolomeSteroid metabolomeReference subjectsCortisol secretionSteroid profileSteroid productionUrine steroid profileSubgroup of patientsArea under the curveHigh-resolution mass spectrometry assayCross-sectional studyCircadian cortisol secretionMass spectrometry assayAndrogen ratioFree cortisolSerum measurementsCircadian secretionPatientsMetabolomicsSteroidsSeparate daysUrineSecretionGlucocorticoid
2023
Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study
Li D, Zhang C, Saini J, Singh S, Nathani R, Thangamuthu K, Suresh M, Atkinson E, Achenbach S, Van Gompel J, Young W, Bancos I. Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study. European Journal Of Endocrinology 2023, 189: 40-49. PMID: 37327378, PMCID: PMC10376436, DOI: 10.1093/ejendo/lvad069.Peer-Reviewed Original ResearchConceptsMild autonomous cortisol secretionQuality of lifeReduced muscle strengthCushing's syndromeMuscle strengthEndogenous hypercortisolismComponent scoresPhysical component of SF36Sit-to-stand test performanceHealth-related quality of lifeSF36 mental component scoreMuscle functionSeverity scoreReference subjectsMental component scorePhysical component scoreHealth-related qualityAutonomous cortisol secretionClinical severity scoreMuscle strength impairmentCross-sectional studyDeterminants of muscle functionStrength impairmentsAdrenal CSEctopic CS
2022
LBSAT59 Overnight Metyrapone Test And Urine Steroid Profiling In Patients Treated With Chronic Opioid Therapy: Prevalence Of Adrenal Insufficiency
Saini J, Gilliam W, Cunningham J, Thangamuthu K, Gruber L, Singh S, Sutor B, Hooten W, Bancos I. LBSAT59 Overnight Metyrapone Test And Urine Steroid Profiling In Patients Treated With Chronic Opioid Therapy: Prevalence Of Adrenal Insufficiency. Journal Of The Endocrine Society 2022, 6: a45-a46. PMCID: PMC9626924, DOI: 10.1210/jendso/bvac150.094.Peer-Reviewed Original ResearchOpioid-induced adrenal insufficiencyOvernight metyrapone testUrine steroid profileMetyrapone testExposure to opioidsDehydroepiandrosterone sulfateSteroid profileOpioid therapyAdrenal insufficiencyDiagnosis of adrenal disordersPrevalence of adrenal insufficiencyPatients treated with opioidsMorphine milligram equivalents (MME)/dayTreated with high dosesChronic opioid therapyMeasurement of ACTHDehydroepiandrosterone sulfate concentrationsCumulative opioid exposureQuality-of-life surveyChronic opioidsCross-sectional studyOpioid exposureAdrenal disordersSteroid metabolomeDaily MME