THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Singh S, Fell V, Atkinson E, Achenbach S, Khosla S, Bancos I. THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.135. PMCID: PMC10554199, DOI: 10.1210/jendso/bvad114.135.Peer-Reviewed Original ResearchArea under the curveAutonomous cortisol secretionParathyroid hormoneBone metabolism biomarkersCortisol secretionFree cortisolType 1 collagenBone metabolismReference subjectsCircadian cortisol secretionCarboxy-terminal telopeptide of type 1 collagenMetabolic biomarkersMild autonomous cortisol secretionIncreased risk of fractureCross-sectional study of patientsCortisol productionParathyroid hormone productionDexamethasone suppression testRisk of fractureCarboxy-terminal telopeptideImpaired bone metabolismStudy of patientsCircadian secretory patternClinical research unitIncreased cortisol productionTHU603 Bone Fragility In Mild Autonomous Cortisol Secretion: A Cross-Sectional Cohort Study
Zhang C, Singh S, Saini J, Suresh M, Thangamuthu K, Nathani R, Ebbehøj A, Fell V, Achenbach S, Atkinson E, Khosla S, Bancos I. THU603 Bone Fragility In Mild Autonomous Cortisol Secretion: A Cross-Sectional Cohort Study. Journal Of The Endocrine Society 2023, 7: bvad114.133. PMCID: PMC10554138, DOI: 10.1210/jendso/bvad114.133.Peer-Reviewed Original ResearchTrabecular bone scoreBone mineral densityDual-energy X-ray absorptiometryAutonomous cortisol secretionBone turnover markersAdrenal nodulesReference subjectsTurnover markersHR-pQCTBone massBone metabolismDecreased TBSTrabecular volumetric bone mineral densityCross-sectional single-center studyMedian age of study participantsOvernight dexamethasone suppression testCortisol secretionVolumetric bone mineral densityAnalysis of bone turnover markersNon-dominant radiusHigh-resolution peripheral quantitative computed tomographyCross-sectional cohort studySingle-center studyAge of study participantsIncreased fracture risk