Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis
Witte M, Schumacher A, Mahler C, Bewersdorf J, Lehmitz J, Scheiter A, Sánchez P, Williams P, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M. Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron 2019, 101: 615-624.e5. PMID: 30686733, PMCID: PMC6389591, DOI: 10.1016/j.neuron.2018.12.023.Peer-Reviewed Original ResearchConceptsAxonal lossModel of multiple sclerosisSodium-calcium exchangerCytoplasmic calcium levelsMultiple sclerosis modelMultiple sclerosis patientsCalcium entryCalcium influxCalcium levelsCalcium imagingCalcium accumulationGlutamate excitotoxicityPersistent disabilityAxonal degenerationMultiple sclerosisAxonsPlasma membraneEndoplasmic reticulumCalcium