2017
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Molecular Psychiatry 2017, 23: 1652-1658. PMID: 29133949, PMCID: PMC5951741, DOI: 10.1038/mp.2017.215.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAutoimmune diseasesChronic tic disorderIndividual autoimmune diseasesThird-degree relativesTic disordersRisk of ADsNational Patient RegisterPatterns of comorbidityFirst-degree relativesPatient RegisterPlacental transmissionNationwide studyBirth cohortCTD casesFamilial clusteringDisordersComorbiditiesPopulation controlsProbandsOCD probandsBiological relativesDiseaseFamilial linkRisk
2002
Maternal behavior and developmental psychopathology
Leckman JF, Herman AE. Maternal behavior and developmental psychopathology. Biological Psychiatry 2002, 51: 27-43. PMID: 11801229, DOI: 10.1016/s0006-3223(01)01277-x.Peer-Reviewed Original ResearchConceptsMaternal behaviorNeuronal nitric oxide synthaseEstrogen alpha receptorsNitric oxide synthaseMouse strain backgroundDopamine beta hydroxylaseGene knockout dataAnimal model systemsGene knockout studiesGene knockout technologyPeer-reviewed journalsOxide synthaseAlpha receptorsBehavioral deficitsSearch of literatureBeta hydroxylaseDisease pathogenesisTranscription factorsMolecular basisGenetic factorsKnockout studiesSpecific genesKnockout dataKnockout technologyStrain background