2020
Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort
Macul Ferreira de Barros P, do Rosário MC, Szejko N, Polga N, Requena GL, Ravagnani B, Fatori D, Batistuzzo MC, Hoexter MQ, Rohde LA, Polanczyk GV, Leckman JF, Miguel EC, de Alvarenga PG. Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort. European Child & Adolescent Psychiatry 2020, 30: 89-104. PMID: 32076869, DOI: 10.1007/s00787-020-01495-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsRisk factorsAbsence of breastfeedingOCS scoresBaseline anxiety disordersPotential risk factorsLarge community cohortLow socioeconomic statusRegression analysisMental health assessmentMaternal stress levelsLower intelligence quotientCommunity cohortChildhood adversityLower ageHigher OCS scoresAnxiety disordersPsychopathological factorsSocioeconomic statusGenetic factorsSignificant predictorsBaselineHealth assessmentScoresAge
2016
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder
Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.Peer-Reviewed Original Research
2014
Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study
Dalsgaard S, Kvist AP, Leckman JF, Nielsen HS, Simonsen M. Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 302-310. PMID: 24956171, PMCID: PMC4137345, DOI: 10.1089/cap.2014.0020.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderProspective cohort studyCardiovascular eventsCohort studyDose-response relationshipStimulant treatmentCardiovascular safetyHazard ratioRisk factorsFirst nationwide cohort studyNationwide prospective cohort studyPossible dose-response relationshipUnique personal identification numberCardiovascular adverse eventsCardiovascular risk factorsHyperactivity disorderNationwide cohort studyNational health registersStimulant usersPopulation-based sampleAdverse eventsHealth registersProspective followCox regressionPotential confounders
2010
Adverse Effects of Heavy Prenatal Maternal Smoking on Attentional Control in Children With ADHD
Motlagh MG, Sukhodolsky DG, Landeros-Weisenberger A, Katsovich L, Thompson N, Scahill L, King RA, Peterson BS, Schultz RT, Leckman JF. Adverse Effects of Heavy Prenatal Maternal Smoking on Attentional Control in Children With ADHD. Journal Of Attention Disorders 2010, 15: 593-603. PMID: 20616372, PMCID: PMC3974616, DOI: 10.1177/1087054710374576.Peer-Reviewed Original ResearchConceptsConnors' Continuous Performance TestContinuous Performance TestAttentional controlPrenatal maternal smokingStroop Color-Word Interference TestColor-Word Interference TestMaternal smokingVisual-Motor Integration TestRisk factorsBeery Visual-Motor Integration TestReaction time variabilityVisual-motor integrationSlower reaction timesDevelopment of ADHDFine motor coordinationNeuropsychological batteryPurdue Pegboard TestHeavy maternal smokingMaternal cigarette smokingPerinatal risk factorsMaternal psychosocial stressMotor inhibitionNeurobiological basisNeuropsychological deficitsADHDSevere psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome
Motlagh MG, Katsovich L, Thompson N, Lin H, Kim YS, Scahill L, Lombroso PJ, King RA, Peterson BS, Leckman JF. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. European Child & Adolescent Psychiatry 2010, 19: 755-764. PMID: 20532931, PMCID: PMC3932440, DOI: 10.1007/s00787-010-0115-7.Peer-Reviewed Original ResearchConceptsHeavy maternal smokingPerinatal risk factorsAttention-deficit/hyperactivity disorderSevere psychosocial stressRisk factorsMaternal smokingTourette syndromePsychosocial stressUnaffected control childrenControl childrenHeavy cigarette smokingHigh-risk populationStatistical significanceDiagnosis of ADHDComorbid Tourette's syndromeHigh rateMothers of childrenMaternal report dataHeavy smokingPerinatal historyCigarette smokingOdds ratioPsychiatric assessmentSmokingStandardized questionnaire
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepression
2000
The Psychiatric Symptoms of Rheumatic Fever
Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosário-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC. The Psychiatric Symptoms of Rheumatic Fever. American Journal Of Psychiatry 2000, 157: 2036-2038. PMID: 11097972, DOI: 10.1176/appi.ajp.157.12.2036.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderRheumatic feverSydenham's choreaTic disordersHigh riskComparison groupFever groupMajor depressive disorderDeficit hyperactivity disorderObsessive-compulsive disorderDepressive disorderRisk factorsPsychiatric symptomsPsychiatric disordersChoreaFeverNeuropsychiatric disordersObsessive-compulsive symptomsRating ScaleHyperactivity disorderSymptomsDisordersADHD symptomsChildrenSemistructured interviews