Antineural antibody in patients with Tourette’s syndrome and their family members
Yeh CB, Wu CH, Tsung HC, Chen CW, Shyu JF, Leckman JF. Antineural antibody in patients with Tourette’s syndrome and their family members. Journal Of Biomedical Science 2005, 13: 101-112. PMID: 16215701, DOI: 10.1007/s11373-005-9033-y.Peer-Reviewed Original ResearchConceptsAntineural antibodiesTourette syndromeTS patientsTic disordersControl groupFirst-degree family membersAge-matched control groupFamily membersSera of controlsImmunological pathophysiologyStreptococcal infectionPrimary cell culturesPatientsInfectious agentsSyndromeNeuropsychiatric disordersWestern blottingAntibodiesRat tissuesInteraction of geneticsGenetic vulnerabilitySerumDisordersFuture studiesCell culturesA family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives