2020
Effect of Temporary Interruption of Warfarin Due to an Intervention on Downstream Time in Therapeutic Range in Patients With Atrial Fibrillation (from ORBIT AF)
Madhavan M, Holmes DN, Piccini JP, Freeman JV, Fonarow GC, Hylek EM, Kowey PR, Mahaffey KW, Pieper K, Peterson ED, Chan PS, Allen LA, Singer DE, Naccarelli GV, Reiffel JA, Steinberg BA, Gersh BJ, Investigators O. Effect of Temporary Interruption of Warfarin Due to an Intervention on Downstream Time in Therapeutic Range in Patients With Atrial Fibrillation (from ORBIT AF). The American Journal Of Cardiology 2020, 132: 66-71. PMID: 32826041, DOI: 10.1016/j.amjcard.2020.07.006.Peer-Reviewed Original ResearchConceptsInternational normalized ratioFirst therapeutic international normalized ratioTherapeutic international normalized ratioTherapeutic rangeAtrial fibrillationMajor bleedingTemporary interruptionAF patientsSubtherapeutic international normalized ratioBetter Informed TreatmentLow therapeutic rangeProportional hazards modelOutcomes RegistryNormalized ratioHigh incidenceLower riskHazards modelPatientsInformed TreatmentWarfarinSubsequent outcomesMonthsAnticoagulationRank testWeeks
2019
Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation
Loring Z, Shrader P, Allen LA, Blanco R, Chan PS, Ezekowitz MD, Fonarow GC, Freeman JV, Gersh BJ, Mahaffey KW, Naccarelli GV, Pieper K, Reiffel JA, Singer DE, Steinberg BA, Thomas LE, Peterson ED, Piccini JP. Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation. American Heart Journal 2019, 219: 21-30. PMID: 31710841, PMCID: PMC7285625, DOI: 10.1016/j.ahj.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCardiovascular DiseasesCause of DeathComorbidityCoronary Artery DiseaseDiabetes MellitusDisease ProgressionEmbolismFemaleGuideline AdherenceHeart FailureHumansHyperlipidemiasHypertensionIntracranial EmbolismMalePeripheral Nervous System DiseasesPeripheral Vascular DiseasesRegistriesSleep Apnea, ObstructiveTreatment OutcomeConceptsGuideline-directed therapyAtrial fibrillationCause mortalityHeart failureAF progressionLower riskNew-onset heart failureObstructive sleep apnea patientsCox proportional hazards modelBetter Informed TreatmentObstructive sleep apneaSleep apnea patientsProportional hazards modelAF patientsDiabetes mellitusNeurovascular eventsClinical outcomesOutcomes RegistrySleep apneaApnea patientsComorbiditiesHazards modelNonsignificant trendPatientsLower mortality