2022
PO-634-05 RATES AND PREDICTORS OF HOSPITAL AND EMERGENCY DEPARTMENT CARE AFTER CATHETER ABLATION OF ATRIAL FIBRILLATION
Friedman D, Freeman J, Wong C, Febre J, Khanna R, Piccini J. PO-634-05 RATES AND PREDICTORS OF HOSPITAL AND EMERGENCY DEPARTMENT CARE AFTER CATHETER ABLATION OF ATRIAL FIBRILLATION. Heart Rhythm 2022, 19: s181. DOI: 10.1016/j.hrthm.2022.03.929.Peer-Reviewed Original Research
2020
Shared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions
Ali-Ahmed F, Pieper K, North R, Allen LA, Chan PS, Ezekowitz MD, Fonarow GC, Freeman JV, Go AS, Gersh BJ, Kowey PR, Mahaffey KW, Naccarelli GV, Pokorney SD, Reiffel JA, Singer DE, Steinberg BA, Peterson ED, Piccini JP, O’Brien E. Shared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 6: 263-272. PMID: 32392287, PMCID: PMC7778449, DOI: 10.1093/ehjqcco/qcaa040.Peer-Reviewed Original ResearchConceptsAtrial fibrillationTreatment decisionsHealthcare providersNew-onset atrial fibrillationHalf of patientsAvailable therapeutic optionsBetter Informed TreatmentHCP recommendationOutcomes RegistryRhythm controlTherapeutic optionsPatient understandingHigher oddsPatientsInformed TreatmentUS sitesFibrillationFuture interventionsPotential targetHigher likelihoodSelf-reported understandingTreatmentSDMSubstudyOptionsDecline in renal function and oral anticoagulation dose reduction among patients with atrial fibrillation
Inohara T, Holmes DN, Pieper K, Blanco RG, Allen LA, Fonarow GC, Gersh BJ, Hylek EM, Ezekowitz MD, Kowey PR, Reiffel JA, Naccarelli GV, Chan PS, Mahaffey KW, Singer DE, Freeman JV, Steinberg BA, Peterson ED, Piccini JP. Decline in renal function and oral anticoagulation dose reduction among patients with atrial fibrillation. Heart 2020, 106: heartjnl-2019-315792. PMID: 31911503, DOI: 10.1136/heartjnl-2019-315792.Peer-Reviewed Original ResearchConceptsAtrial fibrillationRenal functionOral anticoagulationDose reductionAtrial Fibrillation II registryBetter Informed TreatmentML/minCrCl declineOral anticoagulantsCreatinine clearanceOutcomes RegistryGuideline criteriaPatientsPackage insertsUS FoodDrug AdministrationMean declineInformed TreatmentNOACsAnticoagulationFibrillationRegistryDosingCrClOne-fourth
2019
Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation
Pokorney SD, Holmes DN, Shrader P, Thomas L, Fonarow GC, Mahaffey KW, Gersh BJ, Kowey PR, Naccarelli GV, Freeman JV, Singer DE, Washam JB, Peterson ED, Piccini JP, Reiffel JA. Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation. American Heart Journal 2019, 220: 145-154. PMID: 31812756, DOI: 10.1016/j.ahj.2019.09.017.Peer-Reviewed Original ResearchConceptsUse of amiodaroneAmiodarone useAntiarrhythmic drugsAtrial fibrillationAF patientsDifferent antiarrhythmic drugsGuideline-based indicationsPropensity-matched cohortEffective antiarrhythmic drugProportional hazard modelingORBIT-AF registryLogistic regression modelsHierarchical logistic regressionCause mortalityAF RegistryCardiovascular hospitalizationAmiodaroneHigh incidencePatientsClinical practiceHazard modelingLogistic regressionAdverse effectsRandom interceptFibrillationASSOCIATION BETWEEN GUIDELINE-DIRECTED MEDICAL THERAPIES FOR COMORBID CONDITIONS AND CLINICAL OUTCOMES AMONG INDIVIDUALS WITH ATRIAL FIBRILLATION
Loring Z, Shrader P, Allen L, Blanco R, Chan P, Ezekowitz M, Fonarow G, Freeman J, Gersh B, Mahaffey K, Naccarelli G, Pieper K, Reiffel J, Singer D, Steinberg B, Peterson E, Piccini J. ASSOCIATION BETWEEN GUIDELINE-DIRECTED MEDICAL THERAPIES FOR COMORBID CONDITIONS AND CLINICAL OUTCOMES AMONG INDIVIDUALS WITH ATRIAL FIBRILLATION. Journal Of The American College Of Cardiology 2019, 73: 476. DOI: 10.1016/s0735-1097(19)31084-8.Peer-Reviewed Original Research
2018
Response to: “Enlisting Emergency Medicine Clinicians to Help Reduce Strokes in High‐Risk Patients With Atrial Fibrillation and Flutter”
Hsu JC, Freeman JV. Response to: “Enlisting Emergency Medicine Clinicians to Help Reduce Strokes in High‐Risk Patients With Atrial Fibrillation and Flutter”. Clinical Pharmacology & Therapeutics 2018, 104: 615-615. PMID: 30006932, DOI: 10.1002/cpt.1143.Peer-Reviewed Original ResearchASSOCIATION BETWEEN ELEVATED B-TYPE NATRIURETIC PEPTIDE, DISEASE PROGRESSION, AND CLINICAL OUTCOMES AMONG PATIENTS WITH ATRIAL FIBRILLATION
Inohara T, Kim S, Pieper K, Blanco R, Allen L, Fonarow G, Gersh B, Ezekowitz M, Kowey P, Reiffel J, Naccarelli G, Chan P, Mahaffey K, Singer D, Freeman J, Steinberg B, Peterson E, Piccini J. ASSOCIATION BETWEEN ELEVATED B-TYPE NATRIURETIC PEPTIDE, DISEASE PROGRESSION, AND CLINICAL OUTCOMES AMONG PATIENTS WITH ATRIAL FIBRILLATION. Journal Of The American College Of Cardiology 2018, 71: a507. DOI: 10.1016/s0735-1097(18)31048-9.Peer-Reviewed Original ResearchUnderuse of Vitamin K Antagonist and Direct Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A Contemporary Review
Hsu JC, Freeman JV. Underuse of Vitamin K Antagonist and Direct Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A Contemporary Review. Clinical Pharmacology & Therapeutics 2018, 104: 301-310. PMID: 29328506, DOI: 10.1002/cpt.1024.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStroke preventionVitamin K antagonistsDirect oral anticoagulantsNonvalvular AF patientsOral anticoagulant therapyRisk of strokeSpecial patient populationsSerious clinical problemOAC therapyK antagonistsOral anticoagulantsAnticoagulant therapyAF patientsPatient populationLeading causeClinical problemPatientsSignificant deleterious impactPreventionFibrillationTherapyContemporary reviewStrokeUnderuse
2017
NUISANCE BLEEDING IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE OUTCOMES REGISTRY FOR BETTER INFORMED TREATMENT OF ATRIAL FIBRILLATION (ORBIT-AF)
O'Brien E, Simon D, Thomas L, Singer D, Kowey P, Naccarelli G, Fonarow G, Reiffel J, Ansell J, Go A, Chan P, Ezekowitz M, Gersh B, Allen L, Freeman J, Mahaffey K, Piccini J, Peterson E, Hylek E. NUISANCE BLEEDING IN ANTICOAGULATED PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE OUTCOMES REGISTRY FOR BETTER INFORMED TREATMENT OF ATRIAL FIBRILLATION (ORBIT-AF). Journal Of The American College Of Cardiology 2017, 69: 536. DOI: 10.1016/s0735-1097(17)33925-6.Peer-Reviewed Original Research
2015
Heart rate is associated with progression of atrial fibrillation, independent of rhythm
Holmqvist F, Kim S, Steinberg BA, Reiffel JA, Mahaffey KW, Gersh BJ, Fonarow GC, Naccarelli GV, Chang P, Freeman JV, Kowey PR, Thomas L, Peterson ED, Piccini JP. Heart rate is associated with progression of atrial fibrillation, independent of rhythm. Heart 2015, 101: 894. PMID: 25732748, PMCID: PMC4453487, DOI: 10.1136/heartjnl-2014-307043.Peer-Reviewed Original ResearchConceptsAtrial fibrillationAF progressionHeart rateBaseline ECGRhythm control strategyBetter Informed TreatmentPredictors of progressionPersistent atrial fibrillationModest discriminatory powerLower heart rateHigher heart rateMore comorbiditiesOutcomes RegistryPatientsClinical practiceInformed TreatmentProgressionStrongest predictorFibrillationPredictorsBaselineAgeECGSustained formsSignificant interaction
2014
Digoxin and Risk of Death in Adults With Atrial Fibrillation
Freeman JV, Reynolds K, Fang M, Udaltsova N, Steimle A, Pomernacki NK, Borowsky LH, Harrison TN, Singer DE, Go AS. Digoxin and Risk of Death in Adults With Atrial Fibrillation. Circulation Arrhythmia And Electrophysiology 2014, 8: 49-58. PMID: 25414270, PMCID: PMC4334705, DOI: 10.1161/circep.114.002292.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAnti-Arrhythmia AgentsAtrial FibrillationCaliforniaChi-Square DistributionDigoxinFemaleHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedPatient SelectionPropensity ScoreProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsRisk of deathIncident atrial fibrillationAtrial fibrillationDigoxin useHigh riskHeart failureIndependent associationPropensity score-matched adultsKaiser Permanente NorthernPrevious heart failureRetrospective cohort studyResearch Network StudySubgroups of ageCohort studyCox regressionAdverse outcomesRisk factorsHospitalizationFibrillationDigoxinDeathLimited dataAdultsRiskHigh rate