2018
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications
Rattray Z, Dubljevic V, Rattray NJW, Greenwood DL, Johnson CH, Campbell JA, Hansen JE. Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications. Biochemical And Biophysical Research Communications 2018, 496: 858-864. PMID: 29374508, DOI: 10.1016/j.bbrc.2018.01.139.Peer-Reviewed Original Research
2017
Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids
Johnson CH, Santidrian AF, LeBoeuf SE, Kurczy ME, Rattray NJW, Rattray Z, Warth B, Ritland M, Hoang LT, Loriot C, Higa J, Hansen JE, Felding BH, Siuzdak G. Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids. Cancer & Metabolism 2017, 5: 9. PMID: 29093815, PMCID: PMC5663111, DOI: 10.1186/s40170-017-0171-2.Peer-Reviewed Original ResearchLung metastasesMFP tumorsMammary fat pad tumorsCholesterol sulfateCancer cellsPrimary mammary fat pad tumorSpontaneous tumor metastasisMouse xenograft modelPathway analysisDistant organ sitesPrimary cancerNormal lungMouse modelXenograft modelOrgan sitesMetastasisMetastatic nicheDNA/RNA synthesisTumor cellsCancer metastasisNormal tissuesTumor metastasisTumorsDistant sitesMetabolic characteristics
2009
Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo.
Heinze E, Baldwin S, Chan G, Hansen J, Song J, Clements D, Aragon R, Nishimura R, Reeves M, Weisbart R. Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo. International Journal Of Oncology 2009, 35: 167-73. PMID: 19513564, DOI: 10.3892/ijo_00000325.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalApoptosisBreast NeoplasmsCaspase 3Cell Line, TumorCell SurvivalColorectal NeoplasmsDose-Response Relationship, DrugFemaleForkhead Transcription FactorsHumansImmunoconjugatesImmunoglobulin FragmentsLiver NeoplasmsMiceMice, Inbred BALB COvarian NeoplasmsRecombinant Fusion ProteinsTransfectionConceptsColon cancer metastasisCancer cellsCancer metastasisColon cancer cellsBALB/c miceProtein therapyImmune suppressive functionCell deathDose-dependent cell deathRegulatory cellsTumor burdenClinical efficacySyngeneic modelC miceNuclear transcription factorMouse modelSuppressive functionInhibits metastasisMetastasisZ-VAD-FMKClinical potentialTherapyCaspase-3Foxp3Cell killing
2007
Antibody-Mediated p53 Protein Therapy Prevents Liver Metastasis In vivo
Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-Mediated p53 Protein Therapy Prevents Liver Metastasis In vivo. Cancer Research 2007, 67: 1769-1774. PMID: 17308119, DOI: 10.1158/0008-5472.can-06-3783.Peer-Reviewed Original ResearchConceptsLiver metastasesMetastasis ScoreBALB/c miceCancer metastasisCancer cellsMediator of intracellularColon cancer metastasisProtein therapySplenic injectionClinical efficacyControl miceDelivery of p53Significant clinical potentialC micePortal veinColon cancer cellsImmunohistochemical stainingMouse modelSecond injectionMetastasisClinical potentialMiceTherapyVivoP53
2006
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nature Neuroscience 2006, 9: 234-242. PMID: 16415866, DOI: 10.1038/nn1630.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCognitive deficitsDrebrin lossMental retardationP21-activated kinase pathwaysTransgenic mouse modelDendritic spine morphogenesisPotential causal roleP21-activated kinaseHippocampal neuronsDendritic spinesMouse modelΒ-amyloidAdult miceMemory impairmentDiseaseProtein drebrinSpine morphogenesisCausal roleCofilin pathologyDeficitsPAK pathwayPathologyPAK inhibitionKinase pathway