2015
The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults
Kerstetter JE, Bihuniak JD, Brindisi J, Sullivan RR, Mangano KM, Larocque S, Kotler BM, Simpson CA, Cusano A, Gaffney-Stomberg E, Kleppinger A, Reynolds J, Dziura J, Kenny AM, Insogna KL. The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 2214-2222. PMID: 25844619, PMCID: PMC4454800, DOI: 10.1210/jc.2014-3792.Peer-Reviewed Original ResearchConceptsBone mineral densityBone resorptionL-spine bone mineral densitySelf-reported protein intakeDual-energy X-ray absorptiometryTruncal lean massPlacebo-controlled trialGlomerular filtration rateBody mass indexProtein supplementationC-terminal telopeptideX-ray absorptiometryFat-free massWhey protein supplementHigh-protein dietHealthy older adultsOlder Caucasian adultsUrine calciumRenal functionMass indexSkeletal healthUsual dietFiltration rateMineral densityBone mass
2014
Normal Pediatric Data for Isovolumic Acceleration at the Lateral Tricuspid Valve Annulus—A Heart Rate – Dependent Measure of Right Ventricular Contractility
Weismann CG, Bamdad MC, Abraham S, Ghiroli S, Dziura J, Hellenbrand WE. Normal Pediatric Data for Isovolumic Acceleration at the Lateral Tricuspid Valve Annulus—A Heart Rate – Dependent Measure of Right Ventricular Contractility. Echocardiography 2014, 32: 541-547. PMID: 25039533, DOI: 10.1111/echo.12681.Peer-Reviewed Original ResearchMeSH KeywordsAccelerationAgingChildConnecticutEchocardiographyElasticity Imaging TechniquesFemaleHeart RateHeart VentriclesHumansImage EnhancementImage Interpretation, Computer-AssistedMaleReference ValuesReproducibility of ResultsSensitivity and SpecificityTricuspid ValveVentricular Function, RightConceptsTricuspid annular plane systolic excursionBody surface areaHeart rateIsovolumic contractionAnnular plane systolic excursionRight ventricular functionRight ventricular contractilityManagement of patientsLateral tricuspid valve annulusCongenital heart diseaseTricuspid valve annulusIsovolumic accelerationRV contractilityRV dysfunctionSystolic excursionRV SEchocardiographic measuresVentricular functionNormal echocardiogramRetrospective studyVentricular contractilityPediatric dataTissue DopplerHeart diseaseValve annulus
2008
Progressive improvement in glucose tolerance following lower-intensity resistance versus moderate-intensity aerobic training in older women.
Dipietro L, Yeckel CW, Dziura J. Progressive improvement in glucose tolerance following lower-intensity resistance versus moderate-intensity aerobic training in older women. Journal Of Physical Activity And Health 2008, 5: 854-69. PMID: 19164820, DOI: 10.1123/jpah.5.6.854.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testFree fatty acidsGlucose toleranceOlder womenFFA concentrationsModerate-intensity aerobic trainingBasal FFA concentrationLight resistance trainingModerate-intensity aerobicLast exercise sessionGlucose tolerance testInactive older womenResistance training groupLevels of FFALow-intensity resistanceTolerance testPlasma glucoseAerobic trainingExercise sessionsSerial improvementInsulin actionOlder peopleTraining groupProgressive improvementGlucose concentration
2007
Effect of Puberty on the Pharmacodynamic and Pharmacokinetic Properties of Insulin Pump Therapy in Youth With Type 1 Diabetes
Swan KL, Weinzimer SA, Dziura JD, Steil GM, Voskanyan GR, Steffen AT, Martin ML, Tamborlane WV. Effect of Puberty on the Pharmacodynamic and Pharmacokinetic Properties of Insulin Pump Therapy in Youth With Type 1 Diabetes. Diabetes Care 2007, 31: 44-46. PMID: 17909083, DOI: 10.2337/dc07-0737.Peer-Reviewed Original Research
2004
The Effect of Aging on the Skeletal Response to Intermittent Treatment with Parathyroid Hormone
Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J, Insogna K. The Effect of Aging on the Skeletal Response to Intermittent Treatment with Parathyroid Hormone. Endocrinology 2004, 146: 1983-1990. PMID: 15618351, DOI: 10.1210/en.2004-0770.Peer-Reviewed Original ResearchConceptsBody bone mineral densitySkeletal responseAged animalsIntermittent treatmentTotal body bone mineral densityYoung adult C57BL/6 miceDaily sc injectionsVehicle-treated animalsTrabecular bone volume fractionYoung adult miceBone mineral densityYoung adult animalsVertebral histomorphometryEffect of ageBone volume fractionParathyroid hormoneC57BL/6 miceSC injectionPTH treatmentMineral densityBody weightOsteoblast numberPTHCultured marrowYounger counterpartsEstimated change in physical activity level (PAL) and prediction of 5-year weight change in men: the Aerobics Center Longitudinal Study
Di Pietro L, Dziura J, Blair SN. Estimated change in physical activity level (PAL) and prediction of 5-year weight change in men: the Aerobics Center Longitudinal Study. International Journal Of Obesity 2004, 28: 1541-1547. PMID: 15543159, DOI: 10.1038/sj.ijo.0802821.Peer-Reviewed Original ResearchConceptsDaily physical activity levelsPhysical activity levelsAverage daily physical activity levelsAerobics Center Longitudinal StudyLow physical activity levelsWeight gainThird examinationWeight changeBody weightClinic-based cohort studySame physical activity levelDaily leisure-time physical activityLeisure-time physical activityActivity levelsLongitudinal studyCohort studyCooper ClinicBrisk walkingHealthy menPhysical activityMedical examinationWeight lossRegression modelingMenExaminationCan Physical Activity Attenuate Aging-related Weight Loss in Older People?
Dziura J, Mendes de Leon C, Kasl S, DiPietro L. Can Physical Activity Attenuate Aging-related Weight Loss in Older People? American Journal Of Epidemiology 2004, 159: 759-767. PMID: 15051585, DOI: 10.1093/aje/kwh105.Peer-Reviewed Original ResearchConceptsPhysical activityBody weightWeight lossAge-related weight lossDisease-related weight lossOlder peopleBaseline body weightTotal activity scoreFrail older peopleEntire followActivity scoreChronic diseasesEpidemiologic studiesOlder ageWeight changeEstablished PopulationsOlder cohortRandom effects regressionNew HavenRate of agingCohortFollowYearsActivityDisease
2003
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science 2003, 300: 1140-1142. PMID: 12750520, PMCID: PMC3004429, DOI: 10.1126/science.1082889.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentAdultAgedAged, 80 and overAgingBlood GlucoseBody Mass IndexFemaleHumansInsulinInsulin ResistanceLiverMaleMiddle AgedMitochondriaMitochondrial DiseasesMuscle, SkeletalNuclear Magnetic Resonance, BiomolecularOxidation-ReductionOxygen ConsumptionPhosphorylationTriglyceridesConceptsInsulin resistanceInsulin-stimulated muscle glucose metabolismType 2 diabetesMuscle glucose metabolismLean body massElderly study participantsAge-associated declineMitochondrial function contributesFat massFat accumulationGlucose metabolismYoung controlsStudy participantsLiver tissueFunction contributesMitochondrial dysfunctionYounger participantsPossible roleMitochondrial oxidativeBody massMagnetic resonance spectroscopyParticipantsDiabetesDysfunctionPathogenesis