2006
Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokinesAlanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S. Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4287-4294. PMID: 16912127, DOI: 10.1210/jc.2006-1010.Peer-Reviewed Original ResearchConceptsIntrahepatic fat accumulationAlanine aminotransferase levelsHepatic fat fractionVisceral fatInsulin sensitivityMagnetic resonance imagingFat accumulationAminotransferase levelsMetabolic syndromeFatty liverInsulin resistanceChildhood obesityResonance imagingLipid metabolismNonalcoholic fatty liver diseaseHispanic race/ethnicityAbdominal fat partitioningSerum aminotransferase elevationFatty liver diseaseBiomarkers of inflammationHepatic fat accumulationReduced insulin sensitivityFat fractionRace/ethnicityAminotransferase elevation
2005
The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning
Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S. The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3731-3737. PMID: 15797955, DOI: 10.1210/jc.2004-2305.Peer-Reviewed Original ResearchConceptsInsulin sensitivityVisceral fatLipid depositionObese insulin-resistant adolescentsObese insulin-sensitive subjectsNormal glucose tolerancePeripheral insulin sensitivityIntramyocellular lipid contentBody mass indexInsulin-sensitive subjectsHyperinsulinemic-euglycemic clampInsulin-resistant adolescentsInsulin-sensitive controlsWide interindividual variationLipid partitioningLower lipid depositionPercent body fatMagnetic resonance imagingImportance of adiponectinObese insulinObese groupGlucose toleranceMass indexObese adolescentsIntramyocellular lipids
2004
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesity
2003
Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation
Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S. Low Adiponectin Levels in Adolescent Obesity: A Marker of Increased Intramyocellular Lipid Accumulation. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2014-2018. PMID: 12727947, DOI: 10.1210/jc.2002-021711.Peer-Reviewed Original ResearchConceptsAdiponectin levelsInsulin sensitivityAdolescent obesityObese adolescentsPutative modulatory effectsLower adiponectin levelsAbdominal fat distributionIntramyocellular lipid contentPlasma adiponectin levelsIntramyocellular lipid accumulationEuglycemic hyperinsulinemic clampTotal body fatMagnetic resonance imagingCentral adiposityPediatric populationInsulin resistanceIntramuscular lipid contentTriglyceride levelsFat distributionLipid contentPlasma triglyceridesFree fatty acidsBody fatModulatory effectsAdiponectin