2003
Physician Knowledge of the Diagnosis and Management of Rocky Mountain Spotted Fever
O'REILLY M, PADDOCK C, ELCHOS B, GODDARD J, CHILDS J, CURRIE M. Physician Knowledge of the Diagnosis and Management of Rocky Mountain Spotted Fever. Annals Of The New York Academy Of Sciences 2003, 990: 295-301. PMID: 12860642, DOI: 10.1111/j.1749-6632.2003.tb07379.x.Peer-Reviewed Original ResearchConceptsHealth districtHigh case fatality rateRocky Mountain Spotted FeverDifferent health districtsInitiation of therapyOnset of rashDevelopment of rashOnset of symptomsPrimary care physiciansAntibiotic of choiceCase fatality ratePublic health districtsAppropriate treatment strategyFamily practice physiciansPercent of physiciansTick-borne illnessAgent of choiceEmergency medicine physiciansChildren 8 yearsNonspecific symptomsAntibiotic therapyAppropriate patientsPediatric patientsCare physiciansMedian time
2001
Clinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia
Lotrič-Furlan S, Avsic-Zupanc T, Petrovec M, Nicholson W, Sumner J, Childs J, Strle F. Clinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia. MSphere 2001, 8: 899-903. PMID: 11527800, PMCID: PMC96168, DOI: 10.1128/cdli.8.5.899-903.2001.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAntibody titersTick biteLong-term clinical consequencesGranulocytic ehrlichiosisIFA antibody titersOnset of feverSerological Follow-UpHigh antibody titersMost time pointsSeronegative patientsSeropositive patientsAdult patientsFebrile illnessPatients 6Initial presentationClinical outcomesAntibody responseClinical evaluationFollow-upReciprocal titersClinical consequencesSerum collectionFirst presentationPatientsProspective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia
Lotrič-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia. Clinical Infectious Diseases 2001, 33: 503-510. PMID: 11462187, DOI: 10.1086/322586.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsBites and StingsBorrelia burgdorferi GroupCohort StudiesEhrlichiaEhrlichia chaffeensisEhrlichiosisEncephalitis Viruses, Tick-BorneEncephalitis, Tick-BorneFemaleFeverHumansLyme DiseaseMaleMiddle AgedProspective StudiesSloveniaTick-Borne DiseasesTicksConceptsFebrile illnessTick biteEhrlichia phagocytophila infectionAcute febrile illnessTickborne diseasesEvidence of infectionBorrelia burgdorferi sensu latoMeningeal involvementProspective studyClinical criteriaBurgdorferi sensu latoTickborne encephalitisProspective assessmentPatientsLaboratory evidenceImportant causeBacterial infectionsIllnessLyme borreliosisInfectionDiseaseResidents of SloveniaEtiologyBiteEncephalitisSerologic evidence of Rickettsia akari infection among dogs in a metropolitan city.
Comer J, Vargas M, Poshni I, Childs J. Serologic evidence of Rickettsia akari infection among dogs in a metropolitan city. Journal Of The American Veterinary Medical Association 2001, 218: 1780-2. PMID: 11394829, DOI: 10.2460/javma.2001.218.1780.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibodyEnzyme immunoassaySerum samplesPossible risk factorsFever group rickettsiaeClinical illnessRoutine careSerologic evidenceSeropositive dogsRisk factorsTime serum samplesIFA testingClinical relevanceImmunofluorescence antibodySerologic surveyRickettsia akariInfectionGroup rickettsiaeDogsTitersCausative agentVeterinary clinicsFurther studiesDog ownersTick infestationFort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus
McCall C, Curns A, Rotz L, Singleton J, Treadwell T, Comer J, Nicholson W, Olson J, Childs J. Fort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus. Vector-Borne And Zoonotic Diseases 2001, 1: 119-127. PMID: 12653142, DOI: 10.1089/153036601316977723.Peer-Reviewed Original ResearchConceptsTick-borne pathogensSerum samplesRetrospective cohort studyDetectable antibody titersPrimary risk factorRisk of transmissionFort ChaffeeFever group rickettsiaeCompatible illnessReactive EIAsTick-borne diseaseCohort studyDoxycycline useAntibody titersRisk factorsTick biteEhrlichial diseasesGroup rickettsiaeDiseaseMore pathogensProbable diseaseSeropositivityIllnessEhrlichia speciesInfection
1999
Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones
Hofmeister E, Glass G, Childs J, Persing D. Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones. Infection And Immunity 1999, 67: 5709-5716. PMID: 10531219, PMCID: PMC96945, DOI: 10.1128/iai.67.11.5709-5716.1999.Peer-Reviewed Original ResearchConceptsC3H/HeJ miceC.B-17 miceLarval Ixodes scapularis ticksMajority of miceB. burgdorferiInfected nymphal ticksIxodes scapularis ticksBurgdorferi antibodiesSecondary challengeHeJ micePrimary isolatesSequential isolatesC3H miceSequential infectionMiceMonoclonal antibodiesBorrelia burgdorferiC expressionScapularis ticksClonal dominanceUnique isolatesMacrorestriction analysisOspC proteinsClonal groupsEnzootic siteComparison of Methods for Introducing and Producing Artificial Infection of Ixodid Ticks (Acari: Ixodidae) with Ehrlichia chaffeensis
Rechav Y, Zyzak M, Fielden L, Childs J. Comparison of Methods for Introducing and Producing Artificial Infection of Ixodid Ticks (Acari: Ixodidae) with Ehrlichia chaffeensis. Journal Of Medical Entomology 1999, 36: 414-419. PMID: 10467766, DOI: 10.1093/jmedent/36.4.414.Peer-Reviewed Original ResearchMolecular Cloning and Characterization of the Ehrlichia chaffeensis Variable-Length PCR Target: an Antigen-Expressing Gene That Exhibits Interstrain Variation
Sumner J, Childs J, Paddock C. Molecular Cloning and Characterization of the Ehrlichia chaffeensis Variable-Length PCR Target: an Antigen-Expressing Gene That Exhibits Interstrain Variation. Journal Of Clinical Microbiology 1999, 37: 1447-1453. PMID: 10203503, PMCID: PMC84798, DOI: 10.1128/jcm.37.5.1447-1453.1999.Peer-Reviewed Original ResearchConceptsOpen reading frameAmino acid sequenceApparent molecular massE. chaffeensisGenomic libraryMolecular cloningReading frameAcid sequenceDifferentiation of isolatesPCR targetsClose homologyMolecular massNucleotide sequencingImmunoreactive proteinDifferent isolatesDNA samplesInterstrain variationGenesRepeat unitsMolecular databasesCell culturesAmblyomma americanum ticksSequencePCR detectionChaffeensis
1998
An epidemiologic and entomologic investigation of a cluster of Rocky Mountain spotted fever cases in Delaware.
Rotz L, Callejas L, McKechnie D, Wolfe D, Gaw E, Hathcock L, Childs J. An epidemiologic and entomologic investigation of a cluster of Rocky Mountain spotted fever cases in Delaware. Delaware Medical Journal 1998, 70: 285-91. PMID: 9662871.Peer-Reviewed Original ResearchConceptsEntomologic investigationsMore symptomsTick-borne illnessCases of RMSFHealth care providersSerologic evaluationMedian ageRMSF casesClinical aspectsCare providersFever casesDelaware DivisionDisease controlFeverPatientsSymptomsTwo-week periodPrevention measuresPublic healthIllnessRiskRMSFHeadacheAttendeesYears
1995
Ehrlichiosis in a Golf-Oriented Retirement Community
Standaert S, Dawson J, Schaffner W, Childs J, Biggie K, Singleton J, Gerhardt R, Knight M, Hutcheson R. Ehrlichiosis in a Golf-Oriented Retirement Community. New England Journal Of Medicine 1995, 333: 420-425. PMID: 7616991, DOI: 10.1056/nejm199508173330704.Peer-Reviewed Original ResearchConceptsE. chaffeensis infectionCase-control studySerologic testingCommunity AMedical history reviewLone star tickRisk of infectionCommunity BAnnual incidenceSerologic evidencePolymerase chain reactionTick biteRetirement communityInfectionEhrlichiosisEndemic diseaseChain reactionEhrlichia chaffeensisHigh rateSurvey participantsPercentTicksInsect repellentOutbreakRecreational activities
1994
Longitudinal Study of Borrelia burgdorferi Infection in New Jersey Outdoor Workers, 1988–1991
Schwartz B, Goldstein M, Childs J. Longitudinal Study of Borrelia burgdorferi Infection in New Jersey Outdoor Workers, 1988–1991. American Journal Of Epidemiology 1994, 139: 504-512. PMID: 8154474, DOI: 10.1093/oxfordjournals.aje.a117033.Peer-Reviewed Original ResearchConceptsRisk factorsRural residenceSeroconversion of antibodiesBorrelia burgdorferi infectionLyme disease seroprevalenceAntibody seropositivitySerologic statusOdds ratioBurgdorferi infectionTick exposureSeroconversionElevated riskHigh riskOutdoor workersAnnual questionnairesMedical problemsLyme diseaseDisease seroprevalenceSeroprevalenceBorrelia burgdorferiLongitudinal studySeropositivityPet ownershipRural residentsRisk
1993
Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers.
Schwartz B, Goldstein M, Childs J. Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers. American Journal Of Public Health 1993, 83: 1746-8. PMID: 8259808, PMCID: PMC1694949, DOI: 10.2105/ajph.83.12.1746.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibodiesAntibodies, BacterialArachnid VectorsBorrelia burgdorferi GroupCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansLyme DiseaseMaleNew JerseyOccupational DiseasesPrevalenceRisk FactorsSalivary Proteins and PeptidesSeroepidemiologic StudiesSurveys and QuestionnairesTicksWorkplaceConceptsOutdoor workersBorrelia burgdorferiCross-sectional studyB. burgdorferi infectionSecond cross-sectional studyEnzyme-linked immunosorbentLyme disease seroprevalenceAntibody seropositivitySalivary gland proteinsBurgdorferi infectionTick exposureHigh riskLyme diseaseDisease seroprevalenceAntibodiesBurgdorferiGland proteinsSeropositivitySeroprevalenceInfectionPrevalenceDiseaseImmunosorbentWorkersAmblyomma americanum: a potential vector of human ehrlichiosis.
Anderson B, Sims K, Olson J, Childs J, Piesman J, Happ C, Maupin G, Johnson B. Amblyomma americanum: a potential vector of human ehrlichiosis. American Journal Of Tropical Medicine And Hygiene 1993, 49: 239-44. PMID: 8357086, DOI: 10.4269/ajtmh.1993.49.239.Peer-Reviewed Original ResearchEntomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York.
Schwartz B, Nadelman R, Fish D, Childs J, Forseter G, Wormser G. Entomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York. American Journal Of Tropical Medicine And Hygiene 1993, 48: 50-7. PMID: 8427388, DOI: 10.4269/ajtmh.1993.48.50.Peer-Reviewed Original ResearchConceptsSaliva antibodiesIndependent predictorsI. damminiLate-stage Lyme diseaseStrong independent predictorEnzyme-linked immunosorbentEngorgement indicesErythema migransProspective studyAntibody responseBiologic markersRisk factorsTick biteTick exposureNormal controlsSubject ageLogistic regressionLyme diseaseSalivary glandsOptical density valuesBiteTick engorgementConsistent changesDemographic correlatesAntibodies
1991
Anti-tick Saliva Antibody: A Biologic Marker of Tick Exposure That Is a Risk Factor for Lime Disease Seropositivity
Schwartz B, Ford D, Childs J, Rothman N, Thomas R. Anti-tick Saliva Antibody: A Biologic Marker of Tick Exposure That Is a Risk Factor for Lime Disease Seropositivity. American Journal Of Epidemiology 1991, 134: 86-95. PMID: 1853864, DOI: 10.1093/oxfordjournals.aje.a115996.Peer-Reviewed Original ResearchLyme borreliosis in an inner-city park in Baltimore.
Schwartz B, Hofmeister E, Glass G, Arthur R, Childs J, Cranfield M. Lyme borreliosis in an inner-city park in Baltimore. American Journal Of Public Health 1991, 81: 803-804. PMID: 2029058, PMCID: PMC1405150, DOI: 10.2105/ajph.81.6.803.Peer-Reviewed Original Research