2020
Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis
Bonner K, Cruz JS, Sacramento GA, de Oliveira D, Nery N, Carvalho M, Costa F, Childs JE, Ko AI, Diggle PJ. Effects of Accounting for Interval-Censored Antibody Titer Decay on Seroincidence in a Longitudinal Cohort Study of Leptospirosis. American Journal Of Epidemiology 2020, 190: 893-899. PMID: 33274738, PMCID: PMC8096484, DOI: 10.1093/aje/kwaa253.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyMicroscopic agglutination test titersAgglutination test titersHigh transmission settingsPoint-source exposureSeroincidence ratesEstimates of infectionRisk factorsTest titersReported casesEpidemiologic implicationsInfection rateMean infection rateSerological samplesSerological assaysLeptospirosis casesInfectionArboviral diseasesTiter dilutionsSeroincidenceSource exposureLeptospirosisSample size estimationInterval
2001
Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy
Holman R, Paddock C, Curns A, Krebs J, McQuiston J, Childs J. Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy. The Journal Of Infectious Diseases 2001, 184: 1437-1444. PMID: 11709786, DOI: 10.1086/324372.Peer-Reviewed Original ResearchConceptsRisk factorsFatal Rocky Mountain Spotted FeverRocky Mountain Spotted FeverOnset of symptomsCase fatality rateTetracycline-class antibioticsPrimary therapyClinical characteristicsOlder patientsAppropriate therapyRMSF casesNonfatal casesNational surveillanceHigh riskSpotted FeverPatientsEffective antibioticsTherapyDeathFeverAntibioticsTreatmentSymptomsFactorsDiseaseSerologic evidence of Rickettsia akari infection among dogs in a metropolitan city.
Comer J, Vargas M, Poshni I, Childs J. Serologic evidence of Rickettsia akari infection among dogs in a metropolitan city. Journal Of The American Veterinary Medical Association 2001, 218: 1780-2. PMID: 11394829, DOI: 10.2460/javma.2001.218.1780.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibodyEnzyme immunoassaySerum samplesPossible risk factorsFever group rickettsiaeClinical illnessRoutine careSerologic evidenceSeropositive dogsRisk factorsTime serum samplesIFA testingClinical relevanceImmunofluorescence antibodySerologic surveyRickettsia akariInfectionGroup rickettsiaeDogsTitersCausative agentVeterinary clinicsFurther studiesDog ownersTick infestationFort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus
McCall C, Curns A, Rotz L, Singleton J, Treadwell T, Comer J, Nicholson W, Olson J, Childs J. Fort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus. Vector-Borne And Zoonotic Diseases 2001, 1: 119-127. PMID: 12653142, DOI: 10.1089/153036601316977723.Peer-Reviewed Original ResearchConceptsTick-borne pathogensSerum samplesRetrospective cohort studyDetectable antibody titersPrimary risk factorRisk of transmissionFort ChaffeeFever group rickettsiaeCompatible illnessReactive EIAsTick-borne diseaseCohort studyDoxycycline useAntibody titersRisk factorsTick biteEhrlichial diseasesGroup rickettsiaeDiseaseMore pathogensProbable diseaseSeropositivityIllnessEhrlichia speciesInfection
1999
An investigation into the possibility of transmission of tick‐borne pathogens via blood transfusion
Arguin P, Singleton J, Rotz L, Marston E, Treadwell T, Slater K, Chamberland M, Schwartz A, Tengelsen L, Olson J, Childs J, Force T. An investigation into the possibility of transmission of tick‐borne pathogens via blood transfusion. Transfusion 1999, 39: 828-833. PMID: 10504117, DOI: 10.1046/j.1537-2995.1999.39080828.x.Peer-Reviewed Original ResearchConceptsNational Guard personnelTick-borne pathogensOnset of symptomsPossibility of transmissionBlood transfusionProbable infectionRisk factorsMultistate investigationBlood samplesProbable casesNational Guard membersStudy designBlood componentsTick-borne diseasesIllnessRecipientsSymptomsInfectionBlood drivesGuard membersBloodVoluntary recallTransfusionFeverPathogensSerologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland.
Comer J, Tzianabos T, Flynn C, Vlahov D, Childs J. Serologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 894-8. PMID: 10403316, DOI: 10.4269/ajtmh.1999.60.894.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBaltimoreCohort StudiesCross ReactionsDrinkingFemaleFluorescent Antibody Technique, IndirectHIV SeropositivityHumansIll-Housed PersonsMaleRickettsiaRickettsia InfectionsRickettsia rickettsiiRisk FactorsSeroepidemiologic StudiesSubstance Abuse, IntravenousUrban PopulationConceptsIntravenous drug usersInner-city BaltimoreDrug usersSerologic evidenceSerum samplesAcute febrile illnessR. rickettsiiR. akariHuman immunodeficiency virusSignificant risk factorsSignificant inverse associationCross-adsorption studiesPresence of antibodiesSingle serum sampleR. akari infectionFrequency of injectionsFever group rickettsiaeFebrile illnessUndetermined etiologyImmunodeficiency virusInverse associationRisk factorsGroup-specific antibodiesDrug useHigh titers
1996
Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md
Comer J, Flynn C, Regnery R, Vlahov D, Childs J. Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md. JAMA Internal Medicine 1996, 156: 2491-2495. PMID: 8944742, DOI: 10.1001/archinte.1996.00440200111014.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus statusB quintanaRisk factorsDrug usersB henselaeDrug useVirus statusHuman immunodeficiency virus-seropositive individualsHuman immunodeficiency virus (HIV) infectionSerum samplesImmunodeficiency virus infectionAvailable serum samplesSignificant risk factorsBehavioral risk factorsPossible risk factorsSignificant inverse associationIndirect immunofluorescent antibodyFrequency of injectionsUrban transmission cyclesBartonella speciesBartonella organismsMode of transmissionCurrent natural historyImmunodeficiency syndrome
1995
A Case-Control Study of Hantavirus Pulmonary Syndrome during an Outbreak in the Southwestern United States
Zeitz P, Butler J, Cheek J, Samuel M, Childs J, Shands L, Turner R, Voorhees R, Sarisky J, Rollin P, Ksiazek T, Chapman L, Reef S, Komatsu K, Dalton C, Krebs J, Maupin G, Gage K, Sewell C, Breiman R, Peters .. A Case-Control Study of Hantavirus Pulmonary Syndrome during an Outbreak in the Southwestern United States. The Journal Of Infectious Diseases 1995, 171: 864-870. PMID: 7706812, DOI: 10.1093/infdis/171.4.864.Peer-Reviewed Original Research
1994
Epidemiologic observations on infection with Rochalimaea species among cats living in Baltimore, Md.
Childs J, Rooney J, Cooper J, Olson J, Regnery R. Epidemiologic observations on infection with Rochalimaea species among cats living in Baltimore, Md. Journal Of The American Veterinary Medical Association 1994, 204: 1775-8. PMID: 8063598, DOI: 10.2460/javma.1994.204.11.1775.Peer-Reviewed Original ResearchConceptsPrevalence of seropositivityRochalimaea sppGroups of catsFeline immunodeficiency virusImmunodeficiency virusT gondiiRisk factorsEpidemiologic observationsR henselaeToxoplasma gondiiSeropositivityRochalimaea henselaeCat ageRochalimaea speciesWidespread infectionInfectionCatsGondiiPrevalenceHenselaeMechanical vectorsLongitudinal Study of Borrelia burgdorferi Infection in New Jersey Outdoor Workers, 1988–1991
Schwartz B, Goldstein M, Childs J. Longitudinal Study of Borrelia burgdorferi Infection in New Jersey Outdoor Workers, 1988–1991. American Journal Of Epidemiology 1994, 139: 504-512. PMID: 8154474, DOI: 10.1093/oxfordjournals.aje.a117033.Peer-Reviewed Original ResearchConceptsRisk factorsRural residenceSeroconversion of antibodiesBorrelia burgdorferi infectionLyme disease seroprevalenceAntibody seropositivitySerologic statusOdds ratioBurgdorferi infectionTick exposureSeroconversionElevated riskHigh riskOutdoor workersAnnual questionnairesMedical problemsLyme diseaseDisease seroprevalenceSeroprevalenceBorrelia burgdorferiLongitudinal studySeropositivityPet ownershipRural residentsRisk
1993
Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease
Glass G, Watson A, LeDuc J, Kelen G, Quinn T, Childs J. Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease. The Journal Of Infectious Diseases 1993, 167: 614-620. PMID: 8095060, DOI: 10.1093/infdis/167.3.614.Peer-Reviewed Original ResearchConceptsHypertensive renal diseaseEnd-stage renal diseaseRenal diseaseAntibody prevalenceHantavirus infectionReference groupRenal disease diagnosisRace-related differencesDialysis groupDialysis patientsRisk factorsInfectionDiseasePatientsProteinuriaUS residentsHantavirusesPrevalenceDiagnosisGroupAssociationDisease diagnosisSame patternHypertensionSeroprevalenceEntomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York.
Schwartz B, Nadelman R, Fish D, Childs J, Forseter G, Wormser G. Entomologic and demographic correlates of anti-tick saliva antibody in a prospective study of tick bite subjects in Westchester County, New York. American Journal Of Tropical Medicine And Hygiene 1993, 48: 50-7. PMID: 8427388, DOI: 10.4269/ajtmh.1993.48.50.Peer-Reviewed Original ResearchConceptsSaliva antibodiesIndependent predictorsI. damminiLate-stage Lyme diseaseStrong independent predictorEnzyme-linked immunosorbentEngorgement indicesErythema migransProspective studyAntibody responseBiologic markersRisk factorsTick biteTick exposureNormal controlsSubject ageLogistic regressionLyme diseaseSalivary glandsOptical density valuesBiteTick engorgementConsistent changesDemographic correlatesAntibodies
1992
Risk factors associated with antibodies to leptospires in inner-city residents of Baltimore: a protective role for cats.
Childs J, Schwartz B, Ksiazek T, Graham R, LeDuc J, Glass G. Risk factors associated with antibodies to leptospires in inner-city residents of Baltimore: a protective role for cats. American Journal Of Public Health 1992, 82: 597-599. PMID: 1546785, PMCID: PMC1694107, DOI: 10.2105/ajph.82.4.597.Peer-Reviewed Original Research
1991
Anti-tick Saliva Antibody: A Biologic Marker of Tick Exposure That Is a Risk Factor for Lime Disease Seropositivity
Schwartz B, Ford D, Childs J, Rothman N, Thomas R. Anti-tick Saliva Antibody: A Biologic Marker of Tick Exposure That Is a Risk Factor for Lime Disease Seropositivity. American Journal Of Epidemiology 1991, 134: 86-95. PMID: 1853864, DOI: 10.1093/oxfordjournals.aje.a115996.Peer-Reviewed Original Research