1982
Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1
Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.Peer-Reviewed Original ResearchConceptsBile acid excretionAcid excretionEffect of chlorpromazineBile acidsRat liverRat liver 1Glutamic oxalacetic transaminase activityHepatic perfusionHepatic functionTransaminase releasePerfusate concentrationPerfusate flowConstant infusionDrug AdministrationBile acid extractionControl liversHepatic clearanceGlutamic pyruvicTransaminase activityExcretionSodium taurocholateLiver 1Eventual excretionLiverChlorpromazine
1980
Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver.
Tavoloni N, Boyer J. Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver. Journal Of Pharmacology And Experimental Therapeutics 1980, 214: 269-74. PMID: 7391977.Peer-Reviewed Original Research
1979
Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin
Elias E, Boyer J. Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin. Science 1979, 206: 1404-1406. PMID: 574316, DOI: 10.1126/science.574316.Peer-Reviewed Original ResearchEffect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver.
Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.Peer-Reviewed Original ResearchConceptsHepatic perfusionPerfusate flowBile secretionBile acid-independent bile secretionSecretory functionBile acid excretionBile secretory functionRat liverEffect of chlorpromazineLiver 20 minLobar distributionHepatic lobeAcid excretionBaseline valuesPerfusate concentrationConstant infusionHepatic ultrastructureBile acidsControl valuesCPZSodium taurocholateLiverPerfusionGM-1Liver plasma membranes
1978
Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver.
Hruban Z, Tavoloni N, Reed J, Boyer J. Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver. Cell Pathology 1978, 26: 289-305. PMID: 416590, DOI: 10.1007/bf02889557.Peer-Reviewed Original Research