Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea
Sellinger M, Ballatori N, Boyer J. Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea. Toxicology And Applied Pharmacology 1991, 107: 369-376. PMID: 1994517, DOI: 10.1016/0041-008x(91)90216-2.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAmino Acid Transport SystemsAmino Acid Transport Systems, NeutralAnimalsCarrier ProteinsCell MembraneLiverMaleMercuric ChlorideMercurySkates, FishSodiumSodium RadioisotopesSubcellular FractionsSymportersConceptsDependent alanine uptakePlasma membrane vesiclesMembrane vesiclesAlanine uptakePrimitive vertebratesPlasma membraneTransport proteinsConcentration-dependent mechanismLiver plasma membrane vesiclesMicroM HgCl2Mammalian hepatocytesAlanine carrierSulfhydryl groupsLittle skateMembrane integrityRaja erinaceaDirect interactionVesiclesVesicle integrityMembrane permeabilityMercurial inhibitionUptake rateDose-dependent mannerHgCl2 concentrationsLiver plasma membranes