2020
The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury
Cai S, Li M, Boyer J. The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury. 2020, 728-736. DOI: 10.1002/9781119436812.ch56.Peer-Reviewed Original ResearchCholestatic liver injuryBile acidsLiver injuryProinflammatory mediatorsInflammatory responseCauses of cholestasisAlcoholic liver diseasePrimary biliary cholangitisConjugated bile acidsEffects of drugsHepatic infiltrationBile acid transporterLiver transplantationViral hepatitisBiliary cholangitisBiliary cirrhosisMetabolic syndromeDuct obstructionLiver diseaseImmune cellsNeutrophil activationPathophysiological levelsCholangitisInflammationInjury
2015
Fibrates and cholestasis
Ghonem NS, Assis DN, Boyer JL. Fibrates and cholestasis. Hepatology 2015, 62: 635-643. PMID: 25678132, PMCID: PMC4515188, DOI: 10.1002/hep.27744.BooksConceptsPrimary sclerosing cholangitisPrimary biliary cirrhosisCholestatic liver diseaseUDCA therapyLiver diseaseUrsodeoxycholic acidNuclear receptorsProgression of PBCHepatic transportersPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaToxic bile constituentsApical sodium-dependent bile salt transporterOnly therapeutic optionCholestatic liver disordersBile acid homeostasisBile acid synthesisBile salt transportersMultidrug resistance protein 3Cytochrome P450PPARα effectLiver transplantationSclerosing cholangitisBiliary cirrhosisLiver failure
1998
Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver
Koeppel T, Trauner M, Albert M, Arrese M, Rios-Velez L, Boyer J. Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. Journal Of Hepatology 1998, 28: 812-819. PMID: 9625316, DOI: 10.1016/s0168-8278(98)80231-6.Peer-Reviewed Original ResearchConceptsBiliary glutathione excretionBile duct injuryCold ischemiaBile flowHepatic bile formationDuct injuryLiver transplantationBiliary tractBiliary excretionRat liverGlutathione excretionBasal bile flow ratesBile formationBile acid-independent bile flowOxidative stressLate reperfusion periodBile duct damageBile flow rateOnset of reperfusionIndependent bile flowBile duct morphologyBiliary glutathione concentrationsWistar rat liverLiver reperfusionDuct damage