2022
Prediction of Distant Metastases After Stereotactic Body Radiation Therapy for Early Stage NSCLC: Development and External Validation of a Multi-Institutional Model
Gao S, Jin L, Meadows H, Shafman T, Gross C, Yu J, Aerts H, Miccio J, Stahl J, Mak R, Decker R, Kann B. Prediction of Distant Metastases After Stereotactic Body Radiation Therapy for Early Stage NSCLC: Development and External Validation of a Multi-Institutional Model. Journal Of Thoracic Oncology 2022, 18: 339-349. PMID: 36396062, DOI: 10.1016/j.jtho.2022.11.007.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyEarly-stage NSCLCBody radiation therapyDistant metastasisStage NSCLCRadiation therapyHigh-risk patient subgroupsExternal validationPatient-level riskMulti-institutional databaseTime-dependent areaGray regression modelsRandom survival forest modelDM riskSystemic therapyPatient subgroupsIndividualized riskNSCLCPatientsDM ratesDiscriminatory performanceRandom survival forestTherapyInternal validationGood calibration
2014
Considerations for Observational Research Using Large Data Sets in Radiation Oncology
Jagsi R, Bekelman J, Chen A, Chen R, Hoffman K, Shih Y, Smith B, Yu J. Considerations for Observational Research Using Large Data Sets in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 11-24. PMID: 25195986, PMCID: PMC4159773, DOI: 10.1016/j.ijrobp.2014.05.013.Peer-Reviewed Original ResearchMeSH KeywordsChecklistComparative Effectiveness ResearchDatabases, FactualDiffusion of InnovationHealth Care CostsHealth Services ResearchHealth SurveysInsurance Claim ReviewMedicareNeoplasmsNomogramsObservational Studies as TopicProfessional PracticePropensity ScorePublication BiasRadiation OncologyRare DiseasesRegistriesResearch DesignSEER ProgramUnited StatesConceptsRadiation oncology communityRadiation oncologyObservational researchHealth services researchObservational studyWell-designed observational studiesOncology communityField of radiation oncologyHealth careServices researchEvaluate causalityObservational analysisData sourcesInternational Journal of Radiation OncologyMethodological expertiseRadiation oncology researchEvaluate evidenceRecognition of limitationsOncologyClinical trialsPotential data sourcesResearch questionsOncology researchHealthMethodological considerations