2023
Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases
Singh C, Theriault B, An Y, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e150-e151. DOI: 10.1016/j.ijrobp.2023.06.971.Peer-Reviewed Original ResearchWhole-brain radiation therapyTreatment of patientsSystemic diseaseBrain metastasesLesion locationIntracranial lesionsPrior whole-brain radiation therapyMultiple brain metastasesBrain radiation therapyUntreated brain metastasesBrain metastasis treatmentCurrent practice patternsSigns/symptomsPresence of symptomsMATERIAL/METHODSImmunotherapy optionsSystemic therapyUntreated lesionsMedical oncologyPerilesional edemaDrug optionsClinical trialsPractice patternsClinical indicationsMetastasis treatment
2022
Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy
Jairam V, Park HS, Yu JB, Bindra RS, Contessa JN, Jethwa KR. Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy. Advances In Radiation Oncology 2022, 7: 100949. PMID: 35521071, PMCID: PMC9065721, DOI: 10.1016/j.adro.2022.100949.Peer-Reviewed Original ResearchWhole-brain radiation therapyBrain radiation therapyRadiation oncologistsPractice patternsRadiation therapyHA-WBRTNeurocognitive declineCommon reasonHippocampal avoidance whole brain radiation therapyNational practice patternsDeleterious cognitive effectsRoutine clinical practiceNeurocognitive preservationBrain metastasesTreatment delayProvider characteristicsEffective treatmentCurrent evidencePearson χMemantineClinical practicePatientsPrior authorizationMajority of respondentsTherapy
2021
Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole-Brain Radiation Therapy
Jairam V, Park H, Yu J, Bindra R, Contessa J, Jethwa K. Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole-Brain Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: e569. DOI: 10.1016/j.ijrobp.2021.07.1536.Peer-Reviewed Original ResearchWhole-brain radiation therapyWhole brain radiotherapyRadiation oncologistsPractice patternsBrain radiotherapyWBRT patientsNeurocognitive declineRadiation therapyCommon reasonCurrent evidenceHippocampal-avoidance whole-brain radiotherapyN-methyl-D-aspartate receptor antagonistConventional whole brain radiotherapyBrain radiation therapyNational practice patternsDeleterious cognitive effectsRoutine clinical practiceT-testMATERIAL/METHODSStudent's t-testMost radiation oncologistsIntracranial controlNeurocognitive preservationBrain metastasesMedication costs
2019
Tumor subtype and other prognostic factors in breast cancer patients with brain metastases: The updated graded prognostic assessment (Breast-GPA).
Sperduto P, Mesko S, Cagney D, Nesbit E, Chan J, Lee J, Breen W, Shi D, Soliman H, Shanley R, Everett A, Masucci L, Remick J, Plichta K, Jain S, Wu C, Bryant J, Yu J, Nakano T, Mehta M. Tumor subtype and other prognostic factors in breast cancer patients with brain metastases: The updated graded prognostic assessment (Breast-GPA). Journal Of Clinical Oncology 2019, 37: 1079-1079. DOI: 10.1200/jco.2019.37.15_suppl.1079.Peer-Reviewed Original ResearchBrain metastasesPrognostic factorsMedian survivalTumor subtypesBreast cancer patientsBreast-GPAExtracranial metastasesCohort ALuminal BLuminal AImproved survivalCancer patientsComplication of breast cancerKaplan-Meier survival estimatesBrain radiation therapyLog-rank testRadiation therapyBasal tumorsPrognostic indexCohort BFatal complicationRetrospective databaseTreatment patternsPrognostic assessmentBreast cancer
2016
Ceritinib enables stereotactic radiosurgery to a previously untreatable symptomatic brain metastasis in a patient with ALK rearranged non-small cell lung cancer
Qian J, Yu J, Gettinger S, Chiang V. Ceritinib enables stereotactic radiosurgery to a previously untreatable symptomatic brain metastasis in a patient with ALK rearranged non-small cell lung cancer. Cancer Treatment And Research Communications 2016, 6: 17-19. DOI: 10.1016/j.ctrc.2016.02.002.Peer-Reviewed Original ResearchNon-small cell lung cancerAnaplastic lymphoma kinaseWhole-brain radiation therapySymptomatic brain metastasesBrain radiation therapyCell lung cancerBrain metastasesStereotactic radiosurgerySystemic therapyLung cancerRadiation therapyActive small-molecule tyrosine kinase inhibitorLarge symptomatic brain metastasisNext-generation ALK inhibitorsSmall molecule tyrosine kinase inhibitorsYear old Caucasian femaleMolecule tyrosine kinase inhibitorsGeneration ALK inhibitorsALK inhibitor crizotinibOld Caucasian femaleKey driver mutationsTyrosine kinase inhibitorsLocal therapyInhibitor crizotinibALK inhibitors
2013
Stereotactic Radiosurgery Versus Stereotactic Radiosurgery and Whole Brain Radiation Therapy for 1-3 Brain Metastases
Lester-Coll N, Dosoretz A, Yu J. Stereotactic Radiosurgery Versus Stereotactic Radiosurgery and Whole Brain Radiation Therapy for 1-3 Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s177. DOI: 10.1016/j.ijrobp.2013.06.458.Peer-Reviewed Original ResearchHealth State Utilities for Patients Who Underwent Gamma Radiosurgery With or Without Whole Brain Radiation Therapy
Wang C, Lester-Coll N, Yu J. Health State Utilities for Patients Who Underwent Gamma Radiosurgery With or Without Whole Brain Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s572. DOI: 10.1016/j.ijrobp.2013.06.1518.Peer-Reviewed Original Research
2012
Radiosurgical Dose Selection for Brain Metastasis
Yu J, Schulder M, Knisely J. Radiosurgical Dose Selection for Brain Metastasis. Progress In Neurological Surgery 2012, 25: 139-147. PMID: 22236675, DOI: 10.1159/000331187.Peer-Reviewed Original ResearchConceptsDose-escalation trialRadiosurgical doseDose selectionVolume of normal tissueRadiosurgery doseRadiation therapyRadiosurgical treatmentSteep dose gradientsRadiosurgical treatment of brain metastasesRadiation Therapy Oncology GroupTreatment of brain metastasesSingle-fraction dosesBrain radiation necrosisRadiosurgical treatment volumeBrain radiation therapyFractionated radiation therapyDose gradientDose deliveryNormal brain tissueAdjacent normal brain tissuePrimary radiosurgeryBrain metastasesRadiation necrosisOncology GroupTreatment volume