Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity
Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi K, Choo Y, Yoon D, Kim M, Ryoo Z. Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity. Endocrine Journal 2018, 65: ej17-0363. PMID: 29434073, DOI: 10.1507/endocrj.ej17-0363.Peer-Reviewed Original ResearchConceptsHigh-fat dietDiet-induced obesityCD3/CD28 stimulationEpididymal white adipose tissueObesity-induced inflammationPlacental growth factorVascular endothelial growth factorT cellsMetabolic disordersTg miceT cell differentiationAdipose tissueHFD miceGrowth factorCD28 stimulationInflammatory T cell differentiationPro-inflammatory cytokines IL-6Mice fed high-fat dietType 17 helper T cellsFed high-fat dietWT-HFD miceSystemic metabolic disordersIsolated T lymphocytesHelper T cellsCytokines IL-6