Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice
Sung Y, Jeong J, Kang R, Choi M, Park S, Kwon W, Lee J, Jang S, Park S, Kim S, Yi J, Choi S, Lee M, Liu K, Dong Z, Ryoo Z, Kim M. Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice. Cell Biochemistry And Function 2019, 37: 139-147. PMID: 30883865, DOI: 10.1002/cbf.3376.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCell growthΒ-cell destructionImportant regulatorLet-7 biogenesisLet-7 regulationPancreatic β-cell functionRole of Lin28Family of miRNAsRecent genome-wide association studiesΒ-cell functionPancreatic β-cell deathCell cycle progressionCell cycle regulatorsLin28/letΒ-cell deathOverexpression of Lin28aMiRNA biogenesisSkeletal myogenesisPrecise modulationEmbryonic developmentLin28a/Pancreatic β-cellsCycle regulatorsCycle progression