Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet
Jang W, Bae K, Kim S, Yu D, Kim H, Ji Y, Park S, Park S, Kang M, Jeong J, Park S, Lee S, Lee I, Kim M, Yoon D, Ryoo Z. Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet. Biochemical And Biophysical Research Communications 2013, 444: 296-301. PMID: 24380856, DOI: 10.1016/j.bbrc.2013.12.094.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseCarrier ProteinsCo-Repressor ProteinsDiet, High-FatDNA-Binding ProteinsGlucose Tolerance TestHomeostasisInsulinLipid MetabolismMiceMice, TransgenicNuclear ProteinsPhosphoenolpyruvate Carboxykinase (GTP)Real-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionWeight GainConceptsPutative zinc finger motifZinc finger motifsNuclear orphan receptor TR4Regulation of metabolismOverexpression of JAZF1Finger motifTranscription factorsNuclear proteinsKey enzymeExpression of JAZF1Lipid homeostasisFat dietNew therapeutic targetsWeight gainLipid accumulationManagement of obesityHigh-fat dietCritical roleJAZF1Lipid metabolismTherapeutic targetBody weight gainMetabolismRegulationDiabetes mellitus